{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:42:59Z","timestamp":1791664979550,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The 595\u2010nm wavelength pulsed dye laser (PDL) is well\u2010established in the treatment of vascular lesions. In June 2023, it received FDA clearance for the treatment of port\u2010wine birthmarks (PWB) and infantile hemangiomas (IH) in the pediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Review the evidence regarding the efficacy, safety, and implications of using PDL for management of pediatric PWB and IH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic literature search was performed to identify peer\u2010reviewed articles and clinical trials published between July 2002 and December 2022 in which PDL was used to treat pediatric PWB and IH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After application of criteria, 33 journal articles with 7725 total patients were included. Only 16 (0.8%) of the 2,033 patients with PWB and 11 (0.2%) of the 5692 patients with hemangioma reported permanent adverse effects including scarring, keloids, or permanent pigmentation change, and none reported blindness or other serious injury. Good, excellent, or complete clearance after PDL\u2013on average or in greater than 50% of patients\u2013was reported in 17 of 19 studies (89%) that reported these measures for PWB, and seven of the seven studies (100%) for IH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 595\u2010nm PDL is an excellent treatment option for early intervention in pediatric patients with PWB or IH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23864","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T04:58:53Z","timestamp":1734411533000},"page":"27-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The 595\u2010nm Wavelength Pulsed Dye Laser for Pediatric Port\u2010Wine Birthmarks and Infantile Hemangiomas: A Systematic Review"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4927-3152","authenticated-orcid":false,"given":"David A.","family":"Hashemi","sequence":"first","affiliation":[{"name":"Department of Dermatology Laser &amp; Skin Surgery Center of New York New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Laser &amp; Skin Surgery Center of New York New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7437-2745","authenticated-orcid":false,"given":"Jordan V.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Laser &amp; Skin Surgery Center of New York New York New York USA"},{"name":"Department of Dermatology Laser &amp; Skin Surgery Center of Pennsylvania Devon Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9803-8276","authenticated-orcid":false,"given":"Roy G.","family":"Geronemus","sequence":"additional","affiliation":[{"name":"Department of Dermatology Laser &amp; Skin Surgery Center of New York New York New York USA"},{"name":"The Ronald O Perelman Department of Dermatology New York University Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"\u201cFDA Clears Candela's Vbeam 595 nm Pulsed Dye Laser for the Treatment of Port Wine Stains and Hemangiomas in the Pediatric Population \u201dPractical Dermatology 2023 https:\/\/practicaldermatology.com\/news\/fda-clears-vbeam-595-nm-pulsed-dye-laser-for-the-treatment-of-port-wine-stains-and-hemangiomas-in-the-pediatric-population?c4src=topic:pediatric:feed."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2021-005437"},{"key":"e_1_2_9_4_1","first-page":"2263","volume-title":"Dermatology","author":"Zachary C. 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