{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:13:42Z","timestamp":1792872822400,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alopecia areata (AA) is a chronic inflammatory disease that affects the hair follicles and sometimes the nails. It usually presents as a single or multiple patches of hair loss on the scalp, but any hair\u2010bearing skin can be involved. AA treatment depends on the severity and extent of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of combined fractional CO<jats:sub>2<\/jats:sub> (FCO<jats:sub>2<\/jats:sub>) laser with topical minoxidil 5% solution versus topical minoxidil 5% solution alone in the treatment of AA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>The study included 150 patients with AA. The patients were collected from outpatient clinics of the Dermatology and Venerology Department, Tanta University Hospitals. Patients were divided into three groups; 60 patients were treated with topical minoxidil 5% solution, 60 patients were treated with FCO<jats:sub>2<\/jats:sub> laser combined with topical minoxidil 5% solution, and the third group of 30 patients represented the control group treated with topical saline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the placebo group, there was a statistically significant improvement in hair growth in the combination group and minoxidil group. In the combination group, 80% of patients showed excellent improvement, 13.3% of patients showed very good improvement, and 6.7% of patients showed good improvement. In the minoxidil group, 53% of patients showed excellent improvement, 40% of patients showed very good improvement, and 6.7% of patients showed good improvement after 3 months of therapy. Side effects were minimal and transient in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical minoxidil 5% solution either alone or in combination with FCO<jats:sub>2<\/jats:sub> laser could be considered a safe and tolerable method for AA treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23876","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T05:44:35Z","timestamp":1736487875000},"page":"154-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fractional CO<sub>2<\/sub> Laser and Minoxidil in the Treatment of Alopecia Areata, A Comparative Study"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8968-1639","authenticated-orcid":false,"given":"Esraa Elsayed","family":"Elhawary","sequence":"first","affiliation":[{"name":"Dermatology, Venereology and Andrology Department, Faculty of Medicine Tanta 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