{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:40:19Z","timestamp":1788864019977,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Study Objective<\/jats:title><jats:p>We present the results of the first feasibility and safety study of a novel multi\u2010modality falloposcope, in 19 volunteers. The falloposcope incorporated multispectral fluorescence imaging (MFI) and optical coherence tomography (OCT) for evaluation of the fallopian tubes (FT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen females undergoing elective salpingectomy were recruited in this IRB\u2010approved study. During a 15\u2010min pause in standard of care surgery, a novel falloposcope was inserted under hysteroscopic guidance and advanced into the FTs. The furthest cannulated segment (proximal, middle, distal) was noted, and acquisition of MFI and OCT images was attempted at each segment in a retrograde fashion. Surgical discard samples from each segment of both FTs were obtained per pathology discretion for ex vivo imaging. All samples were processed for histology to evaluate any device\u2010related injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The falloposcope was inserted into the FTs of 12 patients and successfully cannulated the entire length of the tube to the distal segment in one\u2010third (4\/12) of attempts. OCT and\/or MFI images were obtained of all but one cannulated FT. Cannulation failure was attributed to proximal anatomy or obstruction, tortuosity of the FT, and limited study time. There were no adverse events related to the falloposcopy procedure. Focal epithelial cell denudation in the proximal segments of three patients, without no stromal involvement, was observed by histological examination. OCT images acquired in vivo showed characteristic tissue microstructures but were more susceptible to artifacts compared to ex vivo images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this first\u2010in\u2010human study suggest that falloposcopy with a novel multimodality imaging endoscope is feasible and safe. Future procedural and design modifications will be implemented to improve image quality and cannulation success rates.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23877","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T05:50:22Z","timestamp":1736488222000},"page":"163-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["First Clinical Feasibility and Safety Study of a Novel Multimodality Fallopian Tube Imaging Endoscope"],"prefix":"10.1002","volume":"57","author":[{"given":"Andrew D.","family":"Rocha","sequence":"first","affiliation":[{"name":"Wyant College of Optical Science University of Arizona Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilara J.","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Arizona Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William K.","family":"Drake","sequence":"additional","affiliation":[{"name":"Wyant College of Optical Science University of Arizona Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique B.","family":"Galvez","sequence":"additional","affiliation":[{"name":"Wyant College of Optical Science University of Arizona Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Photini F.","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Arizona Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary N.","family":"Reed","sequence":"additional","affiliation":[{"name":"Clinical and Translational Services University of Arizona Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Heusinkveld","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Arizona Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Barton","sequence":"additional","affiliation":[{"name":"Wyant College of Optical Science University of Arizona Tucson Arizona USA"},{"name":"Department of Biomedical Engineering University of Arizona Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21456"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003295"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479155"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.08.038"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.09.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318269b8b1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06165-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10110433"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00962-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112794"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50743-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1306"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(98)00097-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.12.333"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.21.5.056005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202300002"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.22.7.076012"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/153303460400300612"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86711-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1423128"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-012-0298-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-023-01911-3"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55040081"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0153461"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23003"},{"key":"e_1_2_8_28_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program. 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