{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:24:15Z","timestamp":1789151055128,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Both nonablative fractional (NAFL) laser combined with intense pulsed light (IPL) and picosecond alexandrite laser (PSAL) with diffractive lens array (DLA) have been documented for their efficacy in facial rejuvenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To observe the safety and efficacy of PSAL\u2010DLA and IPL\u2010NAFL in the rejuvenation of Chinese individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Each subject (<jats:italic>n<\/jats:italic>\u2009=\u200918) received three treatments on half of their face, with 1\u2010month interval between treatments. One side of the face was randomly treated with PSAL\u2010DLA, and the other side with IPL\u2010NAFL. Quantitative data of wrinkles, pores, brown spots, and red areas were calculated using the VISIA\u2010CR imaging system 3 months after the final treatment. Secondary outcomes included a 10\u2010point VAS for patient\u2010rated pain sensation, incidence of post\u2010inflammatory hyperpigmentation (PIH), erythema and edema, and overall satisfaction. Adverse events were recorded after each treatment and at each follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 17 Chinese female patients aged 28.2\u2009\u00b1\u20094.3 years completed the study and the 3\u2010month follow\u2010up. The IPL\u2010NAFL side showed a statistically significant improvement in pores compared to baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05); the PSAL\u2010DLA side showed a statistically significant improvement in brown spots compared to baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Compared to PSAL\u2010DLA, the improvement in enlarged pores was better for IPL\u2010NAFL (81.8\u2009\u00b1\u2009128.1 vs. 20.8\u2009\u00b1\u2009132.4, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). In terms of pain, IPL\u2010NAFL was more painful than PSAL\u2010DLA (6\u2009\u00b1\u20091 vs. 4\u2009\u00b1\u20091, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), a longer recovery time for erythema and edema (5\u2009\u00b1\u20091 vs. 2\u2009\u00b1\u20091, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and a higher incidence of PIH (58.8% vs. 23.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Patient satisfaction was higher for PSAL\u2010DLA than for IPL\u2010NAFL (3\u2009\u00b1\u20091 vs. 4\u2009\u00b1\u20090.5, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study results indicated that both IPL\u2010NAFL and PSAL\u2010DLA could improve the photoaging, but within the same number of treatments, IPL\u2010NAFL was slightly more effective for enlarged pores than PSAL\u2010DLA, while PSAL\u2010DLA was more effective for brown spots than IPL\u2010NAFL. Patients were more satisfied with PSAL\u2010DLA, with a shorter postoperative recovery period and a lower incidence of PIH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23879","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T10:04:57Z","timestamp":1739527497000},"page":"195-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Intense Pulsed Light With Nonablative Fractional Laser and Picosecond Alexandrite Laser With Diffractive Lens Array for Noninvasive Facial Rejuvenation"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0805-5757","authenticated-orcid":false,"given":"Jiafang","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Laser and Aesthetic Medicine affiliated to Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Shanghai Jiaotong University, School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Laser and Aesthetic Medicine affiliated to Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwen","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai  People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shutian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai  People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Laser and Aesthetic Medicine affiliated to Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongze","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Shanghai Jiaotong University, School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Laser and Aesthetic Medicine affiliated to Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Laser and Aesthetic Medicine affiliated to Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Shanghai Jiaotong University, School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01377.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.5978\/islsm.17-RE-02"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14709"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22540"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201100083"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S323872"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.3045"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002405"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14810"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22763"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22577"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12925"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23177"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23393"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2001.01002.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.00085.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2014.10.004"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31925"},{"issue":"3","key":"e_1_2_12_20_1","first-page":"273","article-title":"Skin Rejuvenation in Asian Skin: The Analysis of Clinical Effects and Basic Mechanisms of Intense Pulsed Light","volume":"7","author":"Feng Y.","year":"2008","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2011.593488"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1698701"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.08.041"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-024-04028-9"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16115"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23007"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02401.x"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1493513"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700414"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.01.012"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20406"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22752"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13453"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2019.4644"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20512"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T11:45:36Z","timestamp":1741088736000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/lsm.23879"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23879","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}