{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:19:25Z","timestamp":1782476365414,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the effect of non\u2010ablative Er:YAG laser therapy on the symptoms and microbiological conditions of women with recurrent vulvovaginal candidiasis (RVVC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>One hundred and sixty\u2010seven women (mean age 34.1\u2009\u00b1\u20098.57 years) participated in this cohort study. Women diagnosed with RVVC received four vaginal laser therapies within 4 months. At baseline, 3 months, and 9 months after the last laser therapy microbiological assessment, improvement of five bothersome symptoms related to vaginal infection (burning, itching, dyspareunia, dysuria, and abnormal discharge), and the safety of the laser therapy and overall patient satisfaction were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Non\u2010ablative vaginal Er:YAG laser therapy resulted in improvements of all bothersome symptoms and was statistically significant at 3 and 9 months following the therapy. A complete resolution in symptoms (VAS\u2009=\u20090) was observed in 38%\u201374% of women, depending on the symptom. Nine months after therapy, the prevalence of <jats:italic>Candida albicans<\/jats:italic> dropped from 80% to 30%, and a complete elimination of pathogens was detected in 64% of the women. The laser therapy appeared to be effective in the elimination of non\u2010albicans Candida species. A total of 86% of the patients reported being satisfied or very satisfied with the therapy. Only minor and transient adverse effects were recorded during the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Non\u2010ablative vaginal Er:YAG laser therapy proved to be a promising treatment for RVVC in women. The effect was achieved by improving their vaginal health by lowering the load of pathogenic yeast and by promoting the restoration of a favorable environment for normal microflora.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23880","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T09:58:51Z","timestamp":1738231131000},"page":"187-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Impact of Non\u2010Ablative Erbium Laser Therapy on Recurrent Vaginal Candidiasis"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8852-9010","authenticated-orcid":false,"given":"Adrian","family":"Gaspar","sequence":"first","affiliation":[{"name":"Research and Health Department Champagnat University Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Calderon","sequence":"additional","affiliation":[{"name":"Clinica Espacio Gaspar, Olascoaga Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josue Vargas","family":"Mora","sequence":"additional","affiliation":[{"name":"Dr. Josu\u00e9 Vargas Mora Gynecology and Obstetrics Clinic San Jos\u00e9 Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Silva","sequence":"additional","affiliation":[{"name":"Uroclinica: Paso de los Andes Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Fernando","family":"Bojanini","sequence":"additional","affiliation":[{"name":"Juan Fernando Bojanini Clinic Medell\u00edn Antioquia Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jose","family":"Araujo","sequence":"additional","affiliation":[{"name":"Vulviscience Clinic: Av. Juan Bautista Alberdi Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia Lazzaleta","family":"Geada","sequence":"additional","affiliation":[{"name":"Quiron Rotger Clinic Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Clinical Institute of Aesthetic Medicine Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeksin","family":"Helvacioglu","sequence":"additional","affiliation":[{"name":"Gynecology Department Op. Dr. Yeksin Helvac\u0131o\u011flu Karata\u015f Clinic Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Pe\u00f1a","family":"Coello","sequence":"additional","affiliation":[{"name":"Gynecology Laser Department Ginecenter Clinic dr. Alberto Stolzemburg Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delfina","family":"Zelaschi","sequence":"additional","affiliation":[{"name":"Gynecology Division Dermalaser Asunci\u00f3n Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda","family":"Lucas","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas Caracas Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Mitraud","sequence":"additional","affiliation":[{"name":"Mitraud Dermatologia S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Cogorno Clinical Center Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"Cogorno","sequence":"additional","affiliation":[{"name":"University of Miami, Jackson Memorial Hospital Coral Gables Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra Novakov","family":"Miki\u0107","sequence":"additional","affiliation":[{"name":"Poliklinika Novakov i sar. Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Vasilescu","sequence":"additional","affiliation":[{"name":"Gynecology Department Life Memorial Hospital, Medlife Hyperclinic Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.934353"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60917-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"46","article-title":"Novel Minimally Invasive VSP Er:YAG Laser Treatments in Gynecology","volume":"2012","author":"Vizintin Z.","year":"2012","journal-title":"Journal of the Laser and Health Academy"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.03.038"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2015.1078668"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22569"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-021-03317-x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2019.01.023"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2016.05.003"},{"issue":"1","key":"e_1_2_8_12_1","first-page":"1","article-title":"Dual Tissue Regeneration: Non\u2010Ablative Resurfacing of Soft Tissues With FotonaSmooth\u00ae Mode Er: YAG Laser","volume":"2018","author":"Lukac M.","year":"2018","journal-title":"Journal of the Laser and Health Academy"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-019-04148-9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7915813"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2020.1814728"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-021-03474-z"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22789"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.15222"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2018.1436538"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2015.1091805"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2006.00124.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e27239"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-03179-9"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-020-04452-9"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2020.1813098"},{"issue":"1","key":"e_1_2_8_26_1","first-page":"S17","article-title":"Effects of Sub\u2010Ablative Longpulse Er:YAG Laser Irradiation on Recurrent Vaginal Candidiasis \u2013 Preliminary Results","volume":"2019","author":"Gaspar A.","year":"2019","journal-title":"Journal of the Laser and Health Academy"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033114"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T11:44:53Z","timestamp":1741088693000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/lsm.23880"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23880","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,30]]},"assertion":[{"value":"2024-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}