{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:36:13Z","timestamp":1785764173465,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Poikiloderma of Civatte is a benign skin condition characterized by reticulate erythema and hyperpigmentation in sun\u2010exposed areas, predominantly on the neck, cheeks, and chest. Chronic UV exposure leads to vascular proliferation and red cell extravasation resulting in hemosiderin and melanin deposition. While many light\u2010based modalities have been utilized to treat the disorder, the significant vascularity makes it ideally suited for treatment with vascular lasers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to evaluate the safety and efficacy of a new, long\u2010pulse\u2010duration, Nd:YAG laser incorporating a KTP frequency\u2010doubling crystal and cryogen spray cooling for the treatment of Poikiloderma of Civatte.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty subjects with neck and\/or chest redness were enrolled in this study and treated using the 532\u2009nm wavelength to treat neck and chest redness. Four treatments were administered at monthly intervals and pre\u2010 and 2\u2010month posttreatment images were obtained. Images were randomized and evaluated by three physician evaluators for degree of improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average improvement 2\u2010months posttreatment were 74.1\u2009\u00b1\u200920.2% and 68.4\u2009\u00b1\u200920.5% for the neck and chest, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Side effects were minimal and limited to posttreatment erythema, edema, and purpura.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that this new long pulse\u2010duration, Nd:YAG laser incorporating a KTP frequency\u2010doubling crystal using the 532\u2009nm wavelength is safe and effective for the treatment of Poikiloderma of Civatte.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23881","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T05:44:01Z","timestamp":1736487841000},"page":"171-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and Effectiveness of a New 532\u2009nm, Long Pulse\u2010Duration, Variable Pulse Structure Laser for Treatment of Poikiloderma of Civatte"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8202-7893","authenticated-orcid":false,"given":"Eric F.","family":"Bernstein","sequence":"first","affiliation":[{"name":"Main Line Center for Laser Surgery Ardmore Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Wang","sequence":"additional","affiliation":[{"name":"State University of New York Downstate Health Sciences University Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Eason","sequence":"additional","affiliation":[{"name":"Main Line Center for Laser Surgery Ardmore Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01213.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.1301a7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369489"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12686"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01782.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23036"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12424"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.00060.x"},{"issue":"6","key":"e_1_2_8_10_1","first-page":"1191","article-title":"Treatment of Poikiloderma of Civatte With the Potassium Titanyl Phosphate (KTP) Laser","volume":"140","author":"Batta K.","year":"1999","journal-title":"British Journal of Dermatology"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32061.x"},{"issue":"6","key":"e_1_2_8_12_1","first-page":"527","article-title":"Treatment of Poikiloderma of Civatte With Ablative Fractional Laser Resurfacing: Prospective Study and Review of the Literature","volume":"8","author":"Tierney E. P.","year":"2009","journal-title":"Journal of Drugs in Dermatology: JDD"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12648"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-023-03961-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23700"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/dss.0000000000003831"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/dss.0000000000004057"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33091.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.53994"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.34064.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02393.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.36849\/jdd.5638"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22566"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T11:44:42Z","timestamp":1741088682000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,9]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/lsm.23881"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23881","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,9]]},"assertion":[{"value":"2024-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}