{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:15:35Z","timestamp":1784402135786,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of 5\u2010aminolevulinic acid photodynamic therapy (PDT) for high\u2010grade squamous intraepithelial lesions of the cervix associated with high\u2010risk human papillomavirus (HPV) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, 120 patients who received treatment for high\u2010grade squamous intraepithelial lesions of the cervix from March 2023 to March 2024 were followed up prospectively, which were categorized into the PDT and loop electrosurgical excision procedure (LEEP) groups and matched 1:1 using a propensity score. The regression rate of the lesions and the HPV clearance rate were compared between the groups at 6 and 12 months. Factors affecting the clearance rate were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the 6\u2010 and 12\u2010month follow\u2010ups, no significant difference was observed in the rate of lesion regression between the PDT (86.7%, 91.7%) and LEEP groups (85.0%, 93.3%) (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05), nor the HPV clearance rate (55.0%, 76.7% vs. 65.0%, 78.3%) (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Neither group had any lesions that progressed to Grade 3 or invasive cervical carcinoma at follow\u2010up. According to regression analysis, thinprep cytology test (TCT) results influenced lesion regression in the PDT group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared to the LEEP, 5\u2010aminolevulinic acid PDT had a similar rate of lesion regression and HPV clearance for the treatment of high\u2010grade squamous intraepithelial lesions of the cervix; thus, PDT offers an alternative and effective minimally invasive approach.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.70004","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T20:53:41Z","timestamp":1741726421000},"page":"276-283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Topical 5\u2010Aminolevulinic Acid Photodynamic Therapy With the Loop Electrosurgical Excision Procedure for Patients With Cervical High\u2010Grade Squamous Intraepithelial Neoplasia: A Prospective and Propensity\u2010Matched Analysis"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4127-6919","authenticated-orcid":false,"given":"Yao","family":"Yang","sequence":"first","affiliation":[{"name":"International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingying","family":"Sun","sequence":"additional","affiliation":[{"name":"International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Cao","sequence":"additional","affiliation":[{"name":"International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University Shanghai 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