{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:28:44Z","timestamp":1790634524739,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T00:00:00Z","timestamp":1743897600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The erbium\u2010doped yttrium aluminum garnet(Er:YAG) laser therapy has recently emerged as a novel treatment for stress urinary incontinence (SUI) in women. The purpose of this meta\u2010analysis was to evaluate the efficacy and safety of Er:YAG laser therapy in the management of SUI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We conducted a search in the databases MEDLINE, EMBASE, and the Cochrane Library, up to December 2024, to identify randomized controlled trials (RCTs) that mentioned the use of Er:YAG laser therapy for the treatment of SUI. A systematic review and meta\u2010analysis was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The meta\u2010analysis included four publications with a total of 390 patients diagnosed with SUI. Posttreatment analysis revealed statistically significant improvements in the Er:YAG laser therapy group for the 1\u2010h pad test (mean difference [MD]: \u221210.42; 95% confidence interval [CI], \u221217.32 to \u22123.53; <jats:italic>p<\/jats:italic>\u2009=\u20090.003) and the number of subjective cures as assessed by the International Consultation on Incontinence Questionnaire\u2010Short Form (ICIQ\u2010SF) (odds ratio [OR]; 6.21, 95% CI; 1.55\u201324.84, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). However, no significant differences were observed in the change of ICIQ\u2010SF scores (MD: \u22120.15; 95% CI, \u22120.77 to 1.07; <jats:italic>p<\/jats:italic>\u2009=\u20090.75) and Pelvic Organ Prolapse\/Urinary Incontinence Sexual Questionnaire (PISQ\u201012) scores (MD: 0.81; 95% CI, \u22120.24 to 1.85; <jats:italic>p<\/jats:italic>\u2009=\u20090.13). In terms of comfort, pain visual analog score (VAS) was higher in the laser therapy versus sham therapy following both treatment sessions (The pain VAS after session one (MD; 3.72, 95% CI; 3.24\u2013419, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001). The pain VAS after session two(MD; 2.64, 95% CI; 2.12\u20133.15, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001). Regarding adverse events, there were no statistically significant differences between the Er:YAG laser group and the sham group in terms of increased vaginal discharge (OR; 4.64, 95% CI; 0.27\u201378.30, <jats:italic>p<\/jats:italic>\u2009=\u20090.29), vaginal discomfort (OR; 1.31, 95% CI; 0.62\u20132.73, <jats:italic>p<\/jats:italic>\u2009=\u20090.48), and suspected urinary tract infection (UTI) (OR; 3.44, 95% CI; 0.57\u201320.58, <jats:italic>p<\/jats:italic>\u2009=\u20090.18).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our meta\u2010analysis indicates that the Er:YAG laser appears to be a safe and effective treatment option for SUI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.70012","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T06:19:52Z","timestamp":1744006792000},"page":"297-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Efficacy and Safety of Erbium\u2010Doped Yttrium Aluminum Garnet Laser Therapy for Stress Urinary Incontinence: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4928-0464","authenticated-orcid":false,"given":"Huilei","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Urology Liaocheng People's Hospital Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Liaocheng People's Hospital Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yefei","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Urology Liaocheng People's Hospital Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanli","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology Liaocheng People's Hospital Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Urology Liaocheng People's Hospital Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology Liaocheng People's Hospital Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunbo","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Urology Liaocheng People's Hospital Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20798"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.03.016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.6118\/jmm.22017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.12137"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1914037"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.01.045"},{"key":"e_1_2_8_8_1","volume-title":"EAU Guidelines on Urinary Incontinence in Adults","author":"Burkhard 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