{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:24:44Z","timestamp":1788020684438,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Picosecond lasers have been increasingly applied to the treatment of acquired bilateral nevus of Ota\u2010like macules (ABNOMs), and proved safe and effective for adult patients. But there has been limited data concerned with their use in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the efficacy, safety, and correlative influencing factors of a 755\u2009nm picosecond alexandrite laser in treating ABNOMs in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed children with ABNOMs from January 2017 to July 2023 who received the treatment using a 755\u2009nm picosecond alexandrite laser. Treatment parameters used were as follows: 750\u2009ps pulse duration, 2.34\u20134.07\u2009J\/cm\u00b2 fluence, and 2.5\u20133.3\u2009mm spot size. The mean treatment interval was 7 months. The efficacy was evaluated based on a five\u2010point scale according to the percentage of pigmentation clearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 49 pediatric patients were included in this retrospective study. The average age at the beginning of treatment was 16.87 months old (range of 4 months to 59 months). These patients received an average of two treatments, achieving an average of 76% pigment clearance, which corresponded to excellent improvement (75%\u201394%). After the first treatment, six cases reached clinical clearance, and an average of pigment clearance was 61%. The initial efficacy was positively correlated with Fitzpatrick type (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Patients with Fitzpatrick III skin type responded better than patients with Fitzpatrick IV skin type. Besides, the initial efficacy was negatively correlated with the first treatment age and disease duration (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Eight cases developed postinflammatory hyperpigmentation, accounting for 16.3% of the cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 755\u2009nm picosecond alexandrite laser is safe and effective in treating ABNOMs in children. Being younger at the initial treatment, having Fitzpatrick III skin type, and experiencing a shorter disease duration are beneficial for initial efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.70021","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T05:00:27Z","timestamp":1745989227000},"page":"359-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Retrospective Study of Picosecond Alexandrite Laser Treatment for Acquired Bilateral Nevus of Ota\u2010Like Macules in Children"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4375-4574","authenticated-orcid":false,"given":"Wenwen","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cosmetic Laser Surgery Hospital for Skin Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Laser Surgery Hospital for Skin Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"liu","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Laser Surgery Hospital for Skin Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Laser Surgery Hospital for Skin Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Laser Surgery Hospital for Skin Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5336-9192","authenticated-orcid":false,"given":"Tong","family":"Lin","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Chinese Academy of Medical Sciences&amp;Peking Union Medical College Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4298-7600","authenticated-orcid":false,"given":"Yiping","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Laser Surgery Hospital for Skin Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zong","sequence":"additional","affiliation":[{"name":"Nursing Department Chinese Academy of Medical Sciences &amp; Peking Union Medical College Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)80313-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1987.tb07485.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.283"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569527.2017.1287191"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.06.054"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13167"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.12.053"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23245"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23244"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1834-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003542"},{"issue":"2","key":"e_1_2_11_13_1","first-page":"160","article-title":"Factors Affecting Response, Number of Laser Sessions and Complications in Nevus of Ota Treated by Q\u2010Switched Alexandrite Laser: A Retrospective Study","volume":"151","author":"Sami L.","year":"2016","journal-title":"Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Societa Italiana di Dermatologia e Sifilografia"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00637-0"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.04.081"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14153"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(2000)26:4<376::AID-LSM5>3.0.CO;2-J"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2001.01094.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630152607907"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T12:52:39Z","timestamp":1749646359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.70021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/lsm.70021"],"URL":"https:\/\/doi.org\/10.1002\/lsm.70021","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]},"assertion":[{"value":"2025-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}