{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:29:48Z","timestamp":1773469788124,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:00:00Z","timestamp":1746316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This exploratory study was aimed to evaluate the safety and preliminary efficacy of Epicare, a 1940\u2009nm thulium\u2010doped yttrium aluminum perovskite (Tm:YAP) laser, for fractional skin ablation in a swine model. The goal was to assess collagen remodeling and tissue responses across varied laser settings to optimize skin resurfacing applications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Two female domestic swine were subjected to controlled fractional laser ablation using Epicare across 52 marked abdominal sites with varying energy settings. Macroscopic examinations of ablated sites were conducted immediately following ablation and at 1, 3, 7, 14, 22, and 29 days postablation. Histopathological evaluation was conducted immediately posttreatment, and at 1, 7, and 29 days postablation. Observed parameters included epidermal regeneration, dermal remodeling, inflammation, and collagen deposition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Macroscopic evaluations revealed a fractional, clear, and immediate impact of ablation, consisting primarily of erythema and edema, which resolved without complications by Day 14. Histopathological analysis indicated focal, cylinder\u2010like structures associated with necrotic epidermis and dermis, which healed progressively (i.e. from day 1), transitioning to complete epidermal regeneration by Day 7 for most energy settings. By Day 29, advanced collagen deposition and no residual inflammation indicated effective dermal remodeling, consistent with rapid healing and minimal adverse reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Epicare demonstrated a favorable safety profile and effective tissue ablation. These findings support the laser's potential for dermatologic applications while emphasizing the need for further investigation to confirm its efficacy and optimal settings in human clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.70022","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T02:34:07Z","timestamp":1746412447000},"page":"405-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety Assessment of a 1940\u2009nm Tm:YAP Laser for Fractional Skin Ablation in a Swine Model"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8606-8385","authenticated-orcid":false,"given":"Yuval","family":"Ramot","sequence":"first","affiliation":[{"name":"Department of Dermatology Hadassah Medical Center Jerusalem Israel"},{"name":"The Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Steiner","sequence":"additional","affiliation":[{"name":"Preclinical Consultant Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udi","family":"Vazana","sequence":"additional","affiliation":[{"name":"LAHAV CRO Kibbutz Lahav Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rotem","family":"Nahear","sequence":"additional","affiliation":[{"name":"Laser Team Medical Ltd. Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neria","family":"Suliman","sequence":"additional","affiliation":[{"name":"Laser Team Medical Ltd. Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Laser Team Medical Ltd. Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman","family":"Noach","sequence":"additional","affiliation":[{"name":"Laser Team Medical Ltd. Jerusalem Israel"},{"name":"Department of Applied Physics Electro\u2010Optics Engineering Faculty, Jerusalem College of Technology Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Nyska","sequence":"additional","affiliation":[{"name":"Consultant in Toxicologic Pathology Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.0923"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1329413"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S77996"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754211027515"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003079"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20048"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58091308"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.01.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23817"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfacial.2010.38"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S50367"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2011.630083"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20660"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13450"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2011.04.005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22935"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12976"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985811402846"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.7508\/nmrj.2016.01.004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1293\/tox.2022-0079"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623318761348"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01377.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.4.391"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20468"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3275479"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20715"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1293\/tox.2022-0079"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0142-9612(03)00502-7"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T12:52:46Z","timestamp":1749646366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.70022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,4]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/lsm.70022"],"URL":"https:\/\/doi.org\/10.1002\/lsm.70022","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,4]]},"assertion":[{"value":"2025-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}