{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T13:10:10Z","timestamp":1749647410414,"version":"3.41.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Moderate\u2010to\u2010severe acne vulgaris (AV) remains a therapeutic challenge, often demonstrating resistance to standard interventions, including topical agents, oral antibiotics, and systemic retinoids. Nonablative monopolar radiofrequency (NMRF) offers a promising alternative by delivering controlled dermal heating without epidermal disruption. Initial findings from the authors demonstrated significant reductions in inflammatory lesion counts and sebum production following two NMRF sessions administered 4 weeks apart, with results sustained up to 6 months. This updated study extends the evaluation to include additional clinical assessments at 9\u2010 and 12\u2010month posttreatment, providing further insights into the long\u2010term efficacy and safety of this modality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the extended efficacy and safety of NMRF therapy in the management of moderate\u2010to\u2010severe AV, incorporating follow\u2010up assessments at 9\u2010 and 12\u2010month posttreatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 20 participants with moderate\u2010to\u2010severe AV who had been previously enrolled in the authors\u2019 initial investigation. All participants underwent two NMRF sessions, spaced 4 weeks apart, as per the original protocol. Follow\u2010up assessments were conducted at 9\u2010 and 12\u2010month posttreatment. Lesions were categorized as inflammatory (papules, pustules, nodules, cysts) or noninflammatory (comedones). Sebum production was measured quantitatively using a Sebumeter at each follow\u2010up visit. Patient\u2010reported outcomes, including perceived improvement and satisfaction, were also documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the initial 20 participants, 11 completed the 12\u2010month follow\u2010up. Clinical assessments revealed statistically significant reductions in both inflammatory and noninflammatory lesion counts, with the most substantial decreases observed in papules, pustules, nodules, and cysts. Sebum levels continued to decline consistently over the extended follow\u2010up period. Patient satisfaction scores remained high at both time points, and no significant adverse effects were reported, reinforcing the favorable safety and tolerability profile of NMRF therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NMRF is a safe, effective, and minimally invasive treatment for moderate\u2010to\u2010severe AV. The 1\u2010year follow\u2010up data highlight its potential as a long\u2010term treatment option, demonstrating sustained reductions in lesion counts and sebum production following a two\u2010session course.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.70026","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T09:37:13Z","timestamp":1747301833000},"page":"397-404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One\u2010Year Follow\u2010Up of Acne Vulgaris Patients Treated With Nonablative Monopolar Radiofrequency: Efficacy and Safety Assessment"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8393-7963","authenticated-orcid":false,"given":"Woraphong","family":"Manuskiatti","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-6889","authenticated-orcid":false,"given":"Supisara","family":"Wongdama","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayne Bernadeth","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woramate","family":"Bhorntarakcharoen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sariya","family":"Sittiwanaruk","sequence":"additional","affiliation":[{"name":"Department of Dermatology, 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