{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:20:45Z","timestamp":1787934045366,"version":"build-2784847793"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Rosacea is a chronic inflammatory disease that severely affects the quality of life of patients. Intense pulsed light (IPL) has been widely used in treating the erythema and telangiectasia in rosacea patients. However, the mechanism of its use is poorly understood. Our study objectives were to (i) assess the characteristic histological changes in animal models of rosacea with IPL over a microsecond pulse width, (ii) compare the effectiveness of different filter IPL irradiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilized a mouse model of rosacea by injecting the antimicrobial peptide LL\u201037, with IPL operating over a dose of 10\u2009J\/cm<jats:sup>2<\/jats:sup> and several filter: 560\u2013950\u2009nm, 700\u2013950\u2009nm and dual wavelengths range (530\u2013650\u2009nm and 900\u20131200\u2009nm). The single pulse was set to ten sub\u2010pulses with a pulse width of 700\u2009\u03bcs and delay time of 300\u2009\u03bcs, respectively. Two treatment sessions were performed with a 24\u2010h treatment interval. The erythema scoring criteria were used to evaluate the improvement in erythema before and after treatment. The number of blood vessels, inflammatory cells, and skin stratum corneum and keratinocyte permeability were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IPL significantly improved the erythema in rosacea\u2010like mice. The use of a dual band filter at wavelength of 530\u2013650 and 900\u20131200\u2009nm significantly reduced the number of neutrophils in HE staining. Immunohistochemistry staining of CD31 confirmed the reduction of blood vessels. Also, the number of mast cells was reduced markedly with dual wavelength range and 700\u2013950\u2009nm. In addition, skin stratum corneum and keratinocyte permeability improved with 530\u2013650 and 900\u20131200\u2009nm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This novel IPL exhibited advantages in anti\u2010inflammatory and repairing the permeability barrier of the rosacea\u2010like mice skin. Photobiomodulation could potentially serve as the underlying mechanism of the novel IPL in the treatment of rosacea. It is a promising treatment option for rosacea.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.70034","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T05:38:33Z","timestamp":1748583513000},"page":"544-553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Application of a Novel Intense Pulsed Light in the Treatment of Rosacea\u2010Like Mice"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9449-5655","authenticated-orcid":false,"given":"Run","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Dermatology, West China Hospital Sichuan University Chengdu China"},{"name":"Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease\u2010related Molecular Network, West China Hospital Sichuan University Chengdu China"},{"name":"Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbin","family":"Jia","sequence":"additional","affiliation":[{"name":"Lab of Inflammatory Bowel Disease Frontiers Science Center for Disease\u2010Related Molecular Network Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6935-6449","authenticated-orcid":false,"given":"Li","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Dermatology, West China Hospital Sichuan University Chengdu China"},{"name":"Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease\u2010related Molecular Network, West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0512-6502","authenticated-orcid":false,"given":"Xiang","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, West China Hospital Sichuan University Chengdu China"},{"name":"Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease\u2010related Molecular Network, West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1506630"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2017.11.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00595-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03751.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.02.025"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14747"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.10.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.01.077"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14816"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.44288"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836297"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.5638"},{"key":"e_1_2_10_14_1","volume-title":"Intense Pulsed Light (IPL) Therapy. 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