{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:47:04Z","timestamp":1790938024651,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Androgenetic alopecia (AGA) affects at least 80% of men and 50% of women by age 70. This study aimed to assess the efficacy of a non\u2010ablative fractional laser (NAFL) in treating AGA and enhancing hair appearance on the scalp in male and female patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010center, retrospective, observational study. Case files of all subjects, who were treated for improvement of scalp hair appearance using a 1565\u2010nm NAFL at LaserMed Clinic (Lublin, Poland) between February 24, 2020, and January 31, 2023, were reviewed for study inclusion. The authors were not involved in the administration of treatments but reviewed the data that were obtained for the study. Digital images taken before and following laser treatment were gathered and blindly evaluated by non\u2010treating physicians for quality of results. The study's primary efficacy endpoint was the proportion of image sets correctly classified as before and after treatment. Success was defined as correct identification of the posttreatment image as the image demonstrating scalp hair growth and clinical improvement by at least two out of three blinded reviewers. Safety was evaluated based on the incidence of adverse events or safety issues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 132 patients were included in the study, of whom 98 patients had photos of adequate quality for assessing device efficacy. The overall success rate of correct identification of before and after images among the 98a evaluable patients was 96.9% (95% confidence interval: 91.4%\u201398.5%) and remained consistently high (&gt;\u200995%) across the evaluated subgroups (patients with AGA, patients with unknown type of alopecia, males and females). No adverse events were documented in the clinic records for the 132 subjects included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NAFL is a safe and effective method for promoting visible hair growth and improving the appearance of scalp hair.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.70044","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T09:26:06Z","timestamp":1752571566000},"page":"590-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Improvement in Scalp Hair Appearance Following Treatment With a Non\u2010Ablative Fractional Laser: A Retrospective Observational Study"],"prefix":"10.1002","volume":"57","author":[{"given":"Marc R.","family":"Avram","sequence":"first","affiliation":[{"name":"Weill Cornell Medical School\/New York Presbyterian Hospital, Private Practice New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5665-102X","authenticated-orcid":false,"given":"Dawn","family":"Queen","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center, Private Practice New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Shapiro","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5061-8314","authenticated-orcid":false,"given":"Girish","family":"Munavalli","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine New York New York USA"},{"name":"Wake Forest University Winston Salem North Carolina USA"},{"name":"Private Practice Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2015.1009892"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-02994-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013615"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-024-04054-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01880-x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14537"},{"key":"e_1_2_9_8_1","first-page":"56","article-title":"Adverse Effects and Safety of 5\u2010Alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review","volume":"9","author":"Hirshburg J. M.","year":"2016","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S385861"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5070\/D3203021754"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2023.0071"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061724"},{"key":"e_1_2_9_13_1","first-page":"64","article-title":"A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials of United States Food and Drug Administration\u2010Approved, Home\u2010Use, Low\u2010Level Light\/Laser Therapy Devices for Pattern Hair Loss: Device Design and Technology","volume":"14","author":"Lueangarun S.","year":"2021","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200929050-00001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0060-6"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12200"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22684"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01833.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04183.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001619"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2232-8"},{"key":"e_1_2_9_22_1","unstructured":"I.Norman \u201cEvaluation of Non\u2010Ablative Fractional Laser for Hair Regeneration Capabilities in Mice \u201d poster P228 presented at 13th World Congress for Hair Research Dallas TX 6\u20139 April 2024."},{"key":"e_1_2_9_23_1","unstructured":"N.Sadick \u201cA Case Series to Evaluate the Use of Fractional Non\u2010Ablative Laser Treatment in Alopecia Areata \u201d poster P036 presented at 13th World Congress for Hair Research Dallas TX 6\u20139 April 2024."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14624"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_218_20"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16459"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2306-7"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002157"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16173"},{"key":"e_1_2_9_30_1","first-page":"1335","article-title":"A Split\u2010Face Assessment of the Synergistic Potential of Sequential Q\u2010Switched Nd:YAG Laser and 1565\u2009nm Fractional Nonablative Laser Treatment for Facial Rejuvenation in Fitzpatrick Skin Type II\u2013V Patients","volume":"15","author":"Munavalli G.","year":"2016","journal-title":"Journal of Drugs in Dermatology: JDD"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-022-03622-z"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23635"},{"key":"e_1_2_9_33_1","unstructured":"\u201cK242349: FoLix. 21 CFR 878.4810: Laser Surgical Instrument for Use in General and Plastic Surgery and in Dermatology \u201d United States Food and Drug Administration accessed December 3 2024 https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf24\/K242349.pdf."}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T03:47:57Z","timestamp":1758253677000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.70044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/lsm.70044"],"URL":"https:\/\/doi.org\/10.1002\/lsm.70044","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"assertion":[{"value":"2025-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}