{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T10:21:43Z","timestamp":1787394103983,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T00:00:00Z","timestamp":1754784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Sj\u00f6gren's syndrome (SS) is an autoimmune disorder that affects multiple systems, including hypofunction of salivary and lacrimal glands, associated with xerostomia and keratoconjunctivitis sicca. Current treatments for SS aim to alleviate symptoms and prevent complications by providing therapeutic support to patients. In this context, photobiomodulation therapy (PBMT) with low\u2010level laser has demonstrated efficacy in managing conditions associated with reduced salivary flow, including SS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study reports a case of a 17\u2010year\u2010old female patient diagnosed with SS who underwent PBMT targeting the major salivary glands to alleviate symptoms of xerostomia. Fifteen sessions of PBMT were conducted using an infrared low\u2010level semiconductor diode laser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant improvement in salivary flow was observed, increasing from 0.4\u2009to 1.64\u2009mL\/min post\u2010therapy, with results maintained 6 months after the final application. In addition, the patient's initial moderate xerostomia was reduced to mild, as assessed by a questionnaire using a numerical visual scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PBMT with a low\u2010level laser proved to be an effective nonpharmacological therapeutic option for conditions of xerostomia in SS, particularly in young patients. Further studies with larger patient samples are necessary to validate the effectiveness of this promising therapy for this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.70053","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T03:48:13Z","timestamp":1754884093000},"page":"663-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increased Salivary Flow Using Photobiomodulation Therapy in a Patient With Sj\u00f6gren's Syndrome: A Case Report"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8920-3853","authenticated-orcid":false,"given":"Soraya de Mattos Camargo","family":"Grossmann","sequence":"first","affiliation":[{"name":"Department of Dentistry, School of Dentistry Pontif\u00edcia Universidade Cat\u00f3lica de Minas Gerais (PUC Minas) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4537-8865","authenticated-orcid":false,"given":"Laura Casc\u00e3o","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Dentistry, School of Dentistry Pontif\u00edcia Universidade Cat\u00f3lica de Minas Gerais (PUC Minas) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7522-0909","authenticated-orcid":false,"given":"Luiza","family":"Grossmann de Almeida","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine Pontif\u00edcia Universidade Cat\u00f3lica de Minas Gerais (PUC Minas) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8194-1425","authenticated-orcid":false,"given":"Mariana Silveira","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Dentistry, School of Dentistry Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0364-0436","authenticated-orcid":false,"given":"Laura Maria","family":"de Almeida Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Dentistry, School of Dentistry Pontif\u00edcia Universidade Cat\u00f3lica de Minas Gerais (PUC Minas) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9718-0308","authenticated-orcid":false,"given":"Helenice","family":"de Andrade Marigo Grandinetti","sequence":"additional","affiliation":[{"name":"Department of Dentistry, School of Dentistry Pontif\u00edcia Universidade Cat\u00f3lica de Minas Gerais (PUC Minas) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6964-7872","authenticated-orcid":false,"given":"Rinaldo Borges","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Ci\u00eancias M\u00e9dicas de Minas Gerais (Eye Institute) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.12.1275"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39859"},{"issue":"1127417","key":"e_1_2_7_4_1","first-page":"1","article-title":"Pathogenesis and Treatment of Sjogren's Syndrome: Review and Update","volume":"14","author":"Zhan Q.","year":"2023","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-021-00728-6"},{"issue":"3","key":"e_1_2_7_6_1","first-page":"1039","article-title":"Effects of Low\u2010Level Laser Treatment on Mouth Dryness","volume":"34","author":"Vidovic Juras D.","year":"2010","journal-title":"Collegium 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