{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:34:35Z","timestamp":1787312075625,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Sepsis is a systemic inflammatory response syndrome caused by infection, potentially leading to severe organ dysfunction or septic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effects of vascular photobiomodulation (VPBM), on metabolic parameters in hospitalized patients with sepsis, addressing both efficacy and mechanistic insights.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Conducted as a randomized, blind, controlled clinical trial with 30 participants, the study divided patients into a Control Group (CG) and an Intervention Group (VPBMG). The VPBMG received a 660\u2009nm red laser, delivering 180\u2009J of energy, applied to the radial artery for 30\u2009min over 5 consecutive days. The sample was predominantly male, averaging 40 years of age and 80 bpm heart rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From the third day, the VPBMG group showed significant reductions in WBC, PCO\u2082, PaO\u2082, lactate, creatinine, SpO\u2082, and pH levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest VPBM improves sepsis\u2010related clinical and biomarker parameters, offering promise as a therapeutic option for managing this critical condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70054","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T09:54:03Z","timestamp":1755078843000},"page":"667-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Randomized Placebo\u2010Controlled Clinical Trial of Vascular Photobiomodulation in Hospitalized Patients With Sepsis"],"prefix":"10.1002","volume":"57","author":[{"given":"Adriano Correia","family":"de Sousa","sequence":"first","affiliation":[{"name":"Biomedical Engineering Graduation Program Universidade Brasil S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Perossi","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Universidade Metropolitana de Santos S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivaldo Ant\u00f4nio","family":"Parizotto","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Graduation Program Universidade Brasil S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0392-700X","authenticated-orcid":false,"given":"Patricia","family":"Brassolatti","sequence":"additional","affiliation":[{"name":"Department of research and innovation IBRAMED Amparo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Roberta","family":"Tim","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Graduation Program Universidade Brasil S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Assis","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Graduation Program Universidade Brasil S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emigdio Nogueira","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Graduation Program Universidade Brasil S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly Pereira Rodrigues","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Center for Human Sciences and Letters Universidade Federal do Piau\u00ed Teresina Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-7180","authenticated-orcid":false,"given":"Ana Laura Martins","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Graduation Program Universidade Brasil S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"issue":"1","key":"e_1_2_7_2_1","first-page":"67","article-title":"Sepsis Definition: What's New in the Treatment Guidelines","volume":"61","author":"Srzi\u0107 I.","year":"2022","journal-title":"Acta Clinica Croatica [Internet]"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2017.06.013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2688-1"},{"issue":"3","key":"e_1_2_7_5_1","first-page":"1","article-title":"Proposed Mechanisms of Photobiomodulation or Low\u2010Level Light Therapy","volume":"22","author":"Freitas L. 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