{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:20:47Z","timestamp":1759969247740,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to assess the safety and effectiveness of the Symmed radiofrequency (RF)\u2010based device (Termosalud Inc., Gij\u00f3n, Spain) in body contouring and skin appearance improvement treatments for abdomen\/flanks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Eight sessions of Symmed RF were performed in 15 volunteers' abdomen\/flanks. Sessions were conducted every 72\/96\u2009h. To evaluate the efficacy and safety of the device, photographs, body contours, and ultrasound scans of dermal echogenicity, and adipose tissue thickness were taken at baseline and after the treatments. Additionally, a blind evaluation of the photographic results was conducted. Data regarding the satisfaction level of the participants was also obtained through a customized survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the follow\u2010up visit, significant reductions of 2% in body circumference and 9% in fat thickness were detected in the abdomen\/flanks. These effects were accompanied by a significant 12% increase in dermal echogenicity, related to skin collagen content and organization. Furthermore, the blind evaluation of the photographic results revealed an overall visual improvement. A high satisfaction level was reported by the participants and no severe adverse events were detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Symmed treatment is a noninvasive procedure treating skin laxity and reducing abdomen\/flanks circumferences safely and effectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p>This clinical trial is not registered in a publicly accessible database, and no clinical trial registration number is available. At the time of the investigation, the intended use for fat reduction through radiofrequency was not classified as a medical application under European legislation (COUNCIL DIRECTIVE 93\/42\/EEC). In accordance with Spanish and European regulations, only clinical trials evaluating medical devices are required to be registered.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.70059","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T05:11:47Z","timestamp":1757049107000},"page":"708-715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Body Shaping and Skin Appearance Improvement in the Abdomen and Flanks by Radiofrequency Technology"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2839-7687","authenticated-orcid":false,"given":"Alejandra Fern\u00e1ndez","family":"Santos","sequence":"first","affiliation":[{"name":"Termosalud SL., Ata\u00falfo Friera Tarfe, 8 Gij\u00f3n Asturias Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra Iglesias","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Termosalud SL., Ata\u00falfo Friera Tarfe, 8 Gij\u00f3n Asturias Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena Su\u00e1rez","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Termosalud SL., Ata\u00falfo Friera Tarfe, 8 Gij\u00f3n Asturias Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia Huergo","family":"Zapico","sequence":"additional","affiliation":[{"name":"Termosalud SL., Ata\u00falfo Friera Tarfe, 8 Gij\u00f3n Asturias Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana Valero","family":"Freitag","sequence":"additional","affiliation":[{"name":"Termosalud SL., Ata\u00falfo Friera Tarfe, 8 Gij\u00f3n Asturias Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12776"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1524-4725.2006.32019"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"9","article-title":"Noninvasive Radio Frequency for Skin Tightening and Body Contouring","volume":"32","author":"Weiss R. 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