{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:29:40Z","timestamp":1784158180541,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Paronychia is a common side effect of anticancer therapies, particularly epidermal growth factor receptor inhibitors (EGFRIs). Standard treatments often provide limited relief. Pulsed dye laser (PDL) therapy at 595\u2009nm, with vascular\u2010targeting and anti\u2010inflammatory effects, may serve as an effective adjunctive treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the clinical efficacy and safety of adjunctive 595\u2010nm PDL therapy in the treatment of paronychia induced by anticancer drugs, particularly EGFRIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This prospective pre\u2010post study included 70 digits with anticancer drug\u2010induced paronychia, Common Terminology Criteria for Adverse Events [CTCAE] grade 1\u20132, from ten patients. After a 2\u2010week run\u2010in with standardized treatment, participants received 4 weekly sessions of 595\u2010nm PDL therapy. Outcomes\u2014assessed at baseline, each visit, and 2 weeks posttreatment\u2014included erythema index (EI), modified Severity of Paronychia Assessment Tool (SPOT) score, pain, edema, Physician Global Assessment (PGA), patient satisfaction, and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PDL therapy significantly reduced the EI from 1.63 to 1.42 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and edema from 1.67 to 1.45 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Modified SPOT scores improved from 3.61 to 1.99 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with early pain relief observed (4.40\u20131.25; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). PGA improved by Week 3, and patient satisfaction increased from 0 to 100 by Week 5 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PDL adjuvant therapy significantly improves both clinical signs and patient\u2010reported outcomes in anticancer drug\u2010induced paronychia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.70060","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T10:54:31Z","timestamp":1756551271000},"page":"691-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adjunctive Pulsed Dye Laser Therapy for Paronychia Induced by Anticancer Agents"],"prefix":"10.1002","volume":"57","author":[{"given":"Thunyaporn","family":"Pruangmethangkul","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine, Center of Excellence for Skin and Allergy 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