{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:31:22Z","timestamp":1790800282262,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Rosacea is a chronic inflammatory skin condition with a complex pathogenesis involving immune dysregulation and angiogenesis. Q\u2010switched 1064\u2009nm neodymium:yttrium\u2010aluminum\u2010garnet (QSNY) laser has been demonstrated as an effective treatment for rosacea; however, studies investigating histological changes following QSNY treatment are limited. This study aims to evaluate the therapeutic effects of QSNY and explore its underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A rosacea\u2010like mouse model was established by intradermal injection of LL37 into BALB\/c mice. Hematoxylin and eosin (H&amp;E) staining, along with immunohistochemical staining for myeloperoxidase (MPO) and CD31, were performed to assess inflammation and angiogenesis. mRNA expression levels of rosacea\u2010associated markers were analyzed using real\u2010time quantitative PCR (RT\u2010qPCR) on RNA extracted from skin lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>QSNY treatment significantly reduced skin erythema and inflammatory cell infiltration in a rosacea\u2010like mouse model. The number of CD31\u2010 and MPO\u2010positive cells were notably decreased following QSNY treatment. Additionally, the mRNA expression levels of rosacea\u2010associated genes, including Toll\u2010like receptor 2 (TLR2), kallikrein 5 (KLK5), cyclic adenosine monophosphate (cAMP), elevated interleukin\u20101\u03b2 (IL\u20101\u03b2), interleukin\u20106 (IL\u20106), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), vascular endothelial growth factor (VEGF)\u20101, and VEGF\u20102 were downregulated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>QSNY effectively mitigates the rosacea phenotype by suppressing inflammation and angiogenesis, highlighting its potential as a therapeutic strategy for rosacea.<\/jats:p>\n                  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