{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T03:55:27Z","timestamp":1765338927734,"version":"3.46.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n A neurocosmetic post\u2010procedure cream (NPPC) was developed as a semi\u2010breathable topical to provide relief and recovery following energy\u2010based device treatments. The NPPC was investigated following hybrid fractional and fractional ablative laser resurfacing to assess tolerability, safety, and patient compliance and retention, as well as compare against a conventional post\u2010procedure topical routine.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Two randomized, double\u2010blinded, split\u2010face, controlled, procedure\u2010pairing studies were conducted with healthy females aged 35\u201365\u2009years with Fitzpatrick Skin Types I\u2013III and moderate to severe photodamage. Subjects were randomized to apply the NPPC and a comparator moisturizer (CM) or comparator anhydrous formulation (CAF) three times daily for 7 days post\u2010hybrid fractional laser (HFL) or 14 days post\u2010fractional ablative CO\n 2<\/jats:sub>\n laser (FACL), respectively. Tolerability evaluations, questionnaires, and clinical photography were conducted at baseline and post\u2010baseline timepoints.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Sixteen and twenty\u2010two healthy female subjects completed the HFL and FACL studies, respectively. The NPPC was effective at improving erythema, edema, dryness, burning, itching, stinging, and discomfort as evidenced by tolerability evaluations, clinical photography, and questionnaires. There were no significant adverse events. Day 1 post\u2010FACL treatment, 91% of subjects favorably agreed \u201cthe product calmed my skin.\u201d Patient relief and recovery were achieved with the NPPC. Across the two studies, the NPPC performed similarly or better than the conventional postprocedure topical routine investigated. The studies are limited to a small sample size, and the lack of a vehicle\u2010only or untreated control arm is unethical.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n An NPPC developed to soothe skin following energy\u2010based device procedures demonstrated patient tolerability, safety, and improved healing time following hybrid and fractional ablative laser treatments. Patients indicated favorable responses to the treatments, and there was high agreement that they would return for a second treatment, denoting patient retention. The NPPC achieved comparable outcomes versus the conventional postprocedure topical routine in both HFL and FACL studies.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n \n \n \n HFL Study: ClinicalTrials.gov ID<\/jats:bold>\n : NCT06436261\n \n \n \n https:\/\/clinicaltrials.gov\/study\/NCT06436261?term=NCT06436261&rank=1<\/jats:ext-link>\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:list-item>\n \n \n FACL Study: ClinicalTrials.gov ID:<\/jats:bold>\n NCT06366503\n \n \n \n https:\/\/www.clinicaltrials.gov\/study\/NCT06366503?term=NCT06366503&rank=1<\/jats:ext-link>\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n ClinicalTrials.gov registration was completed after study completion for journal publication purposes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lsm.70078","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T04:36:19Z","timestamp":1764045379000},"page":"788-798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Neurocosmetic Postprocedure Cream for Optimal Recovery and Tolerability From Energy\u2010Based Devices"],"prefix":"10.1002","volume":"57","author":[{"given":"Nathan M.","family":"Weir","sequence":"first","affiliation":[{"name":"The Dermatology Group Blue Ash Ohio USA"},{"name":"Present address: DOCS Dermatology Cincinnati, OH 45247 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Burns","sequence":"additional","affiliation":[{"name":"Resurrect Skin MD Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Kononov","sequence":"additional","affiliation":[{"name":"Revision Skincare\u00ae Irving Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6964-0776","authenticated-orcid":false,"given":"Alisar S.","family":"Zahr","sequence":"additional","affiliation":[{"name":"Revision Skincare\u00ae Irving Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2015.0693"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","unstructured":"L.Triana R. M.Palacios Huatuco G.Campilgio andE.Liscano \u201cTrends in Surgical and Nonsurgical Aesthetic Procedures: A 14\u2010Year Analysis of the International Society of Aesthetic Plastic Surgery\u2014ISAPS.\u201d Aesthetic Plastic Surgery (August 5 2024) https:\/\/doi.org\/10.1007\/s00266-024-04260-2.","DOI":"10.1007\/s00266-024-04260-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2016.03.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(97)70106-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20286"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.01.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.10.1295"},{"issue":"8","key":"e_1_2_10_9_1","first-page":"24","article-title":"Review of Post\u2010Laser\u2010Resurfacing Topical Agents for Improved Healing and Cosmesis","volume":"14","author":"Angra K.","year":"2021","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics8030087"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2020.5386"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"e_1_2_10_14_1","unstructured":"A.ZahrandT.Kononov \u201cNovel Pathway in Enhancing Patient Comfort Post\u2010Procedure with a Topical Treatment \u201d paper presented at International Master Course on Aging Science (IMCAS) World Congress Paris France February 1\u20133 2024."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12385"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16622"},{"key":"e_1_2_10_17_1","unstructured":"M. B.Young J.Namnoum A. J.Burns et al. \u201cNovel Post\u2010Procedure Topical Treatment Enhances Patient Comfort Post\u2010Hybrid Fractional Laser \u201d paper presented at 19th Annual Music City Symposium for Cosmetic Advances & Laser Education (SCALE) Nashville TN May 15\u201319 2024."},{"key":"e_1_2_10_18_1","unstructured":"M. B.Young T.Kononov A. S.Zahr andN. M.Weir \u201cPost\u2010Procedure Cream With Unique Neurotopical Technology Improves Patient Experience and Recovery Following Fractional Ablative CO2 Laser Treatment \u201d paper presented at 19th Annual Music City Symposium for Cosmetic Advances & Laser Education (SCALE) Nashville TN May 15\u201319 2024."},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2009.08.009"},{"issue":"1","key":"e_1_2_10_20_1","first-page":"42","article-title":"\u201cUpdate on Fractional Laser Technology","volume":"3","year":"2010","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.582"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2012.01476.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.DSS.0000479796.34703.94"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.99042.x"},{"issue":"7","key":"e_1_2_10_25_1","first-page":"707","article-title":"Randomized, Split\u2010Face\/D\u00e9collet\u00e9 Comparative Trial of Procedure Enhancement System for Fractional Non\u2010Ablative Laser Resurfacing Treatment","volume":"16","author":"Robinson D. M.","year":"2017","journal-title":"Journal of Drugs in Dermatology: JDD"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S392459"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13270"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12339"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01087"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T03:53:43Z","timestamp":1765338823000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.70078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/lsm.70078"],"URL":"https:\/\/doi.org\/10.1002\/lsm.70078","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"type":"print","value":"0196-8092"},{"type":"electronic","value":"1096-9101"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"assertion":[{"value":"2025-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}