{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:40:06Z","timestamp":1772988006460,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Energy\u2010based treatments for atrophic acne scars (AAS) in darker skin phototypes must balance efficacy with pigmentary safety. While the nonablative 675\u2010nm laser has shown promise with minimal risk of adverse effects, prospective data in Asian populations remain limited. This study evaluated the efficacy, tolerability, and safety of a 675\u2010nm laser for AAS in Fitzpatrick skin types (FSTs) III\u2013IV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixteen adults with AAS underwent 3 monthly sessions using sequential Moveo (low\u2010fluence scanning) and Standard (fractional stamping) modes. Outcomes were assessed at baseline and at 1, 3, and 6 months after the final session, including Goodman and Baron quantitative scores (GBQGASGS), Antera\u00ae 3D imaging device, patient satisfaction, procedural pain, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GBQGASGS improved by 14.5% at 6 months after the final treatment (19.81\u2009\u00b1\u20097.31 to 16.94\u2009\u00b1\u20097.18;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), with a 9.7% reduction evident 1 month after the second session (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). Antera\u00ae 3D analysis demonstrated improvements in skin texture (12.91\u2009\u00b1\u20094.25 to 11.38\u2009\u00b1\u20093.97;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and scar volume (2.54\u2009\u00b1\u20091.33 to 2.04\u2009\u00b1\u20091.26;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). At 6 months, blinded evaluators reported \u2265\u200925% improvement in 50% of subjects, while 69% of patients reported \u2265\u200925% improvement. Adverse events were of low incidence and transient in nature, and no serious complications occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The 675\u2010nm laser demonstrated significant and sustained improvements in acne scar metrics in Asian patients with FST III\u2013IV, supporting its role as a pigment\u2010safe, nonablative option for atrophic acne scars in skin of color.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Thai Clinical Trials Registry: TCTR20250218009.\n                    <\/jats:p>\n                  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Bernadeth","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8393-7963","authenticated-orcid":false,"given":"Woraphong","family":"Manuskiatti","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,21]]},"reference":[{"issue":"9","key":"e_1_2_7_2_1","first-page":"16","article-title":"Is Acne the Same Around the World?","volume":"17","author":"Alexis A.","year":"2024","journal-title":"Journal of Clinical and Aesthetic 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