{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:40:09Z","timestamp":1772988009040,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human papillomavirus (HPV) infections are a major cause of oral lesions, and in individuals living with HIV, lesions such as focal epithelial hyperplasia (FEH) may persist or exhibit atypical features, potentially progressing to more severe conditions if untreated. Managing oral HPV lesions in immunocompromised patients is challenging, as conventional therapies may carry higher risks or show limited efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study reports the case of a 49\u2010year\u2010old HIV\u2010positive male with valve disease and arthritis, requiring crutches for mobility. He presented with multiple painless oral lesions, diagnosed as FEH associated with oral HPV, and had previously undergone unsuccessful treatments. Photodynamic therapy (PDT) using methylene blue (MB) and a red laser was proposed as a treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Topical MB\u2010mediated PDT successfully cleared the FEH lesions, with no recurrence observed over 24 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PDT mediated by MB is an effective and affordable approach for treating FEH associated with HPV in immunosuppressed patients, offering favorable outcomes and improved quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70091","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T10:54:03Z","timestamp":1766832843000},"page":"70-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Control of Human Papillomavirus\u2010Related Focal Epithelial Hyperplasia in an Human Immunodeficiency Virus\u2010Positive Patient Using Methylene Blue\u2010Mediated Photodynamic Therapy. A Case Report"],"prefix":"10.1002","volume":"58","author":[{"given":"Juliana Cristina Oliverio de","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"Professional Master Radiation Technology in Health Sciences Nuclear and Energy Research Institute (IPEN\u2010CNEN) S\u00e3o Paulo Brazil"},{"name":"Dental Specialties Center \u201cBrasil Sorridente\u201d Osasco Brazil"},{"name":"Center for Lasers and Applications Nuclear and Energy Research Institute (IPEN\u2010CNEN) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermano Camelo","family":"Paiva","sequence":"additional","affiliation":[{"name":"Dental Specialties Center \u201cBrasil Sorridente\u201d Osasco Brazil"},{"name":"Department of Restorative Dentistry, School of Dentistry University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Margarida Meyer","family":"Faara","sequence":"additional","affiliation":[{"name":"Dental Specialties Center \u201cBrasil Sorridente\u201d Osasco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Og Fray","family":"Junior","sequence":"additional","affiliation":[{"name":"Center for Lasers and Applications Nuclear and Energy Research Institute (IPEN\u2010CNEN) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4203-1134","authenticated-orcid":false,"given":"Martha Sim\u00f5es","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Professional Master Radiation Technology in Health Sciences Nuclear and Energy Research Institute (IPEN\u2010CNEN) S\u00e3o Paulo Brazil"},{"name":"Center for Lasers and Applications Nuclear and Energy Research Institute (IPEN\u2010CNEN) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,27]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"HPV reference clones \u2013 International Human Papillomavirus Reference Center. (2025).https:\/\/www.hpvcenter.se\/human_reference_clones\/."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2014.999570"},{"key":"e_1_2_8_4_1","first-page":"82","article-title":"HPV\u2010Associated Oral Warts","volume":"66","author":"Feller L.","year":"2011","journal-title":"SADJ: journal of the South African Dental Association = tydskrif van die Suid\u2010Afrikaanse Tandheelkundige Vereniging"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-022-01250-1"},{"key":"e_1_2_8_6_1","article-title":"A Comprehensive Review of Treatment Approaches for Cutaneous and Genital Warts","volume":"15","author":"Kore V. 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