{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:40:08Z","timestamp":1772988008034,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Lichen sclerosus (LS) is a chronic inflammatory dermatosis that predominantly affects the genital region, but can also manifest in other areas of the body. Extragenital LS is often less responsive to standard treatments, necessitating alternative modalities. Herein, we describe the case of a young adult man with a 7\u2010year history of an enlarging sclerotic plaque on the right thigh, refractory to high\u2010potency topical corticosteroids and intralesional triamcinolone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The patient underwent three sessions of fractional CO\n                      <jats:sub>2<\/jats:sub>\n                      laser combined with platelet\u2010rich plasma (PRP) therapy over 6 months. Pre\u2010 and post\u2010treatment biopsies were performed to investigate histologic changes associated with the healing response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The treatment resulted in near\u2010complete flattening of the plaque and resolution of dermal sclerosis. A post\u2010treatment biopsy confirmed diminished collagen hyalinization, restoration of elastic fibers, and increased fibroblasts and neovascularization. No recurrence was observed at 1\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This case highlights the potential role of fractional CO\n                      <jats:sub>2<\/jats:sub>\n                      laser combined with PRP as an effective therapeutic option for recalcitrant extragenital LS. Further studies are warranted to validate this combined approach.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70093","type":"journal-article","created":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T07:05:48Z","timestamp":1766905548000},"page":"74-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Treatment of Recalcitrant Extragenital Lichen Sclerosus With Fractional CO\n                    <sub>2<\/sub>\n                    Laser and Platelet\u2010Rich Plasma: A Case Report With Histologic Evaluation"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0754-1104","authenticated-orcid":false,"given":"Paulus Anthony","family":"Halim","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5167-5399","authenticated-orcid":false,"given":"Sondang P.","family":"Sirait","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-6367","authenticated-orcid":false,"given":"Larisa Paramitha","family":"Wibawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4786-3375","authenticated-orcid":false,"given":"Shannaz Nadia","family":"Yusharyahya","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Sie Shun","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_969_21"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04595.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13741"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/gyn.2016.0099"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000004332"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23476"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23669"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.20517\/2347-9264.2021.86"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-022-02397-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1106318"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/ccid.S355111"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12099"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477353"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12780"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-03105-z"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkab016"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2016.1823"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000004409"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-025-04581-x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkaa028"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70093","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.70093","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:14:44Z","timestamp":1772968484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.70093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,27]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/lsm.70093"],"URL":"https:\/\/doi.org\/10.1002\/lsm.70093","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,27]]},"assertion":[{"value":"2025-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}