{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:00:57Z","timestamp":1773853257928,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Given that the therapeutic evidence for doxycycline in rosacea has predominantly been derived from studies on papulopustular rosacea (PPR), this study aimed to evaluate the efficacy and safety of combined oral doxycycline, topical calcineurin inhibitor (TCI), and pulsed dye laser (PDL) therapy in erythematotelangiectatic rosacea (ETR) and to identify clinical predictors of treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Medical photographs of patients with ETR treated with oral doxycycline, TCI, and two subsequent PDL sessions were retrospectively reviewed. Erythema on the right cheek was quantitatively measured using computer\u2010aided image analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 79 included patients, 47 had the ETR subtype and 32 had the mixed ETR\/PPR subtype. Erythema significantly improved after oral doxycycline and TCI treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and further PDL treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Particularly, in\u00a0patients with moderate\u2010to\u2010severe ETR, background erythema improved to a level comparable to that observed in patients with mild ETR after treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.307). Post\u2010treatment erythema did not differ by age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.963) or Fitzpatrick skin type (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.277); however, it was significantly lower among males (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) and in patients without prior steroid treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046). No serious adverse events, including photosensitivity, were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combined oral doxycycline, TCI, and PDL therapy is effective and safe for ETR, especially in patients with higher severity. Prompt diagnosis and avoidance of steroid misuse may improve treatment responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70109","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T07:55:47Z","timestamp":1770796547000},"page":"223-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes and Predictive Factors of Combination Treatment With Oral Doxycycline, Topical Calcineurin Inhibitor, and Pulsed Dye Laser in Erythematotelangiectatic Rosacea"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0590-7894","authenticated-orcid":false,"given":"Minsu","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2223-1606","authenticated-orcid":false,"given":"Bo Ri","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9994-8819","authenticated-orcid":false,"given":"Chong Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5602-3530","authenticated-orcid":false,"given":"Sang Woong","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.25.130"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics11010011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.14"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1616"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555572178179"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(97)00605-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.04.069"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.11.021"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03445.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2010.07345.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.01.023"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15155"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.05.063"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15180"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550510043975"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01991.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08496.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630802032595"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1169916"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.141"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.1303a182"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.037"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-002-8263-8"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.04.010"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1502453"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12075"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2011.7"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17420"},{"issue":"3","key":"e_1_2_6_31_1","first-page":"26","article-title":"Advances in Understanding and Managing Rosacea: Part 2: The Central Role, Evaluation, and Medical Management of Diffuse and Persistent Facial Erythema of Rosacea","volume":"5","author":"Del Rosso J. 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