{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:46:52Z","timestamp":1793933212522,"version":"4.8.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine how serial line\u2010field optical coherence tomography (LC\u2010OCT) imaging can visualize early tissue\u2010response patterns following UltraClear Laser\u2010Coring treatment in a single\u2010subject self\u2010imaging model, with secondary evaluation of the impact of a regenerative serum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single subject self\u2010imaging demonstration was performed using 2910\u2009nm UltraClear Laser\u2010Coring treatments applied to bilateral volar forearms. The left arm received a regenerative serum, while the right arm received petroleum jelly and served as a comparator. Serial dermoscopy and LC\u2010OCT imaging (deepLive LC\u2010OCT system Damae Medical, Paris, France) was performed from Day 1 to Day 18 to document the imaging characteristics of laser\u2010created microchannels over time. LC\u2010OCT features of interest included keratinocyte behavior, nuclear morphology, stratum corneum reformation, and dermal remodeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LC\u2010OCT enabled visualization of progressive epithelial coverage over the laser\u2010induced microchannels, with near\u2010complete surface continuity apparent by Day 4. Stratum corneum\u2010like hyperreflective layering reappeared between Days 4 and 18. Nuclear contour and reflectivity changes on LC\u2010OCT corresponded to expected patterns of cellular activation and maturation. Dermal vessel dilation and increasing fiber definition were observed between Days 8 and 18. No meaningful differences in LC\u2010OCT appearance were observed between serum\u2010treated and control sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LC\u2010OCT proved effective for documenting the in vivo imaging features associated with UltraClear Laser\u2010Coring treatment. Serial LC\u2010OCT imaging revealed distinct epidermal and dermal healing patterns. This technical demonstration supports the feasibility of using LC\u2010OCT to visualize laser\u2010induced tissue effects in real time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70117","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:35:30Z","timestamp":1772962530000},"page":"303-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characterizing Laser\u2010Induced Wound Healing Dynamics Using Line\u2010Field Confocal Optical Coherence Tomography"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4634-7645","authenticated-orcid":false,"given":"Gabriela","family":"Pinero\u2010Crespo","sequence":"first","affiliation":[{"name":"University of South Florida Morsani College of Medicine Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Beachkofsky","sequence":"additional","affiliation":[{"name":"Department of Dermatology James A. Haley Veterans\u2019 Hospital Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20048"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18620"},{"issue":"1","key":"e_1_2_12_4_1","article-title":"Advances in LC\u2010OCT for Non\u2010Invasive Evaluation of Skin Structure and Pathology","volume":"31","author":"Monnier J.","year":"2025","journal-title":"Skin Research and Technology"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23738"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00891.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1983.12"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr010379n"},{"issue":"7","key":"e_1_2_12_9_1","first-page":"618","article-title":"Fractional Laser\u2010Assisted Drug Delivery: An Update","volume":"48","author":"Haedersdal M.","year":"2016","journal-title":"Lasers in Surgery and Medicine"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22227"},{"issue":"3","key":"e_1_2_12_11_1","first-page":"178","article-title":"Imaging Wound Healing Dynamics Using LC\u2010OCT","volume":"110","author":"Boone M. A.","year":"2023","journal-title":"Journal of Dermatological Science"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23841"},{"issue":"4","key":"e_1_2_12_13_1","first-page":"1335","article-title":"Integration of Fractional Ablative Lasers Into Aesthetic Practice","volume":"29","author":"Adatto M. A.","year":"2014","journal-title":"Lasers in Medical Science"},{"issue":"1","key":"e_1_2_12_14_1","first-page":"4","article-title":"The Science Behind Skin Barrier Function","volume":"25","author":"Draelos Z. D.","year":"2012","journal-title":"Dermatologic Therapy"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000556"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.70117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:26:06Z","timestamp":1780989966000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.70117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/lsm.70117"],"URL":"https:\/\/doi.org\/10.1002\/lsm.70117","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,1]]},"assertion":[{"value":"2025-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}