{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:14:27Z","timestamp":1788257667545,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Field cancerization is a major concern in photodamaged skin due to its risk of progression to squamous cell carcinoma. The 1927\u2010nm thulium laser has emerged as a promising therapy, but its isolated effects on this condition remain underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate clinical and histopathological changes in field cancerization treated with the 1927\u2010nm thulium laser.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>It was a prospective, observational, and interventional clinical study. Twenty\u2010three patients (age average of 61.3 years), phototype I\u2013III, with facial photodamage and multiple actinic keratosis underwent 4 monthly sessions of thulium laser, followed by a 3\u2010month evaluation. Outcomes included lesion counts and a photoaging scale at each session, along with comprehensive histological analysis of pre\u2010 and post\u2010treatment biopsies from 20 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a significant reduction in AK count (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and photoaging parameters (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Histologically, we observed improvement in vertical extension of keratinocyte atypia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046), increased dermal thickness (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), and fibroplasia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No severe adverse effects occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 1927\u2010nm thulium laser is a safe, well\u2010tolerated and has promising results as a field\u2010directed therapy for actinic keratosis, promoting both clinical and histopathological improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70119","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:59:22Z","timestamp":1772989162000},"page":"311-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and Histopathological Assessment of the Field of Cancerization in Human Skin Before and After Treatment With a 1927\u2010nm Thulium Fractional Laser"],"prefix":"10.1002","volume":"58","author":[{"given":"Livia Maria Oliveira","family":"Salviano","sequence":"first","affiliation":[{"name":"Department of Dermatology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Bubna","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Pathology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella Soares","family":"Pincelli","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian Nunes","family":"Arruda","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2254-8400","authenticated-orcid":false,"given":"Rodrigo 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