{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T06:25:39Z","timestamp":1785651939919,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Oral isotretinoin is the standard therapy for severe acne. However, scarring may persist. Fractional microneedling radiofrequency (FMRF) improves both inflammatory lesions and scars with minimal downtime. In this study, we compare isotretinoin monotherapy and concurrent isotretinoin and FMRF for active acne regarding clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this parallel two\u2010group comparative study, patients received either low\u2010dose isotretinoin monotherapy for 20 weeks (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934) or low\u2010dose isotretinoin concurrently with 5 monthly FMRF sessions (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936). Outcomes were assessed at baseline and weeks 12, 20, 24, 32, and 44. The primary endpoints were Global Acne Grading System (GAGS) scores and inflammatory\/non\u2010inflammatory lesion counts. Secondary endpoints were hemoglobin indices and skin roughness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The GAGS scores of isotretinoin and FMRF were significantly lower than those of isotretinoin monotherapy from weeks 12\u201344 (\u221279.69% vs. \u221260.34% at week 44, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Isotretinoin and FMRF showed significantly greater lesion count reductions than isotretinoin monotherapy at follow\u2010up visits from weeks 12\u201344. Isotretinoin and FMRF showed significantly lower hemoglobin levels than isotretinoin monotherapy at weeks 32 and 44 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively). Skin surface roughness improved substantially and persistently from week 12\u201344.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early active treatment with isotretinoin and FMRF is safe and better than isotretinoin monotherapy over 44 weeks regarding severity, reduced erythema, and improved surface roughness in moderate\u2010to\u2010severe acne vulgaris. This encourages early and effective treatment of acne to mitigate acne scarring and improve patients' quality of life.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinicaltrials.gov (Or Equivalent) Listing:<\/jats:bold>\n                      Thai Clinical Trials Registry (TCTR20250202008).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70120","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:04:43Z","timestamp":1772978683000},"page":"321-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Low\u2010Dose Oral Isotretinoin Combined With Fractional Microneedle Radiofrequency Versus Low\u2010Dose Oral Isotretinoin Monotherapy in the Treatment of Moderate\u2010To\u2010Severe Acne Vulgaris: A Randomized Controlled Comparative Study"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-4915","authenticated-orcid":false,"given":"Wareeporn","family":"Disphanurat","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine Thammasat University Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pornpirun","family":"Leeyangyuen","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine Thammasat University Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjaporn","family":"Srisantithum","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine Thammasat University Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.17633"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00890.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.045"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12149"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13386"},{"issue":"2","key":"e_1_2_9_8_1","first-page":"97","article-title":"Prevalence and Risk Factors of Acne Scarring Among Patients Consulting Dermatologists in the USA","volume":"16","author":"Tan J.","year":"2017","journal-title":"Journal of Drugs in Dermatology: JDD"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.02.040"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.4487"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00628-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.12.017"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10152.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15974"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02267.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12471"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002972"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16639"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15171"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00099.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12464"},{"issue":"9","key":"e_1_2_9_22_1","first-page":"46","article-title":"The Effects of Oral Isotretinoin on Atrophic Acne Scars Measured by Shear\u2010Wave Elastography: An Observational, Single\u2010Center Study","volume":"16","author":"Turk C. 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