{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:52:23Z","timestamp":1790740343868,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Objectives<\/jats:title>\n Conventional suturing in periodontal flap surgery may increase postoperative discomfort and requires additional visits for suture removal. Cyanoacrylate tissue adhesives and low\u2010level laser therapy (LLLT) have individually shown benefits in wound healing and postoperative symptom reduction. This pilot randomized controlled trial evaluated the feasibility and preliminary clinical outcomes of a sutureless periodontal flap closure technique using cyanoacrylate adhesive with adjunctive LLLT compared with conventional suturing.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This prospective, parallel\u2010group pilot randomized controlled trial was conducted over a 4\u2010month period from October 2025 to January 2026, in the Department of Periodontics, Kothiwal Dental College and Research Centre, Moradabad, India. 20 systemically healthy adults (mean age 31.9\u2009\u00b1\u20093.6 years; 55% males) with Stage II or III, Grade B periodontitis requiring flap surgery were randomly allocated (1:1) to conventional silk sutures (control,\n n<\/jats:italic>\n \u2009=\u200910) or cyanoacrylate adhesive with LLLT (intervention,\n n<\/jats:italic>\n \u2009=\u200910). The primary outcome was postoperative pain measured using a 100\u2010mm visual analog scale. Secondary outcomes included wound healing index, analgesic consumption, plaque index, probing pocket depth (PPD), clinical attachment level (CAL), and patient treatment preference. Statistical analysis was performed using mixed\u2010effects models and generalized linear mixed models, with independent\n t<\/jats:italic>\n \u2010test or Mann\u2013Whitney\n U<\/jats:italic>\n test for between\u2010group comparisons. Statistical significance was set at\n p<\/jats:italic>\n \u2009<\u20090.05, and 95% confidence intervals were calculated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n All participants completed the study with 100% follow\u2010up and no adverse events. Baseline demographic characteristics were comparable between groups (\n p<\/jats:italic>\n \u2009>\u20090.05). The intervention group demonstrated significantly lower analgesic consumption (mean difference 2.30 tablets; 95% confidence interval 1.18\u20133.42;\n p<\/jats:italic>\n \u2009=\u20090.001) and higher patient preference scores (mean difference 1.50 points; 95% confidence interval 0.83\u20132.17;\n p<\/jats:italic>\n \u2009=\u20090.001). Postoperative pain scores were consistently lower and early wound healing scores were higher in the intervention group across follow\u2010up visits (\n p<\/jats:italic>\n \u2009<\u20090.05). Both groups showed significant reductions in probing pocket depth and clinical attachment level at 6 weeks (\n p<\/jats:italic>\n \u2009<\u20090.05), with no statistically significant between\u2010group differences over time (\n p<\/jats:italic>\n \u2009>\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Cyanoacrylate adhesive with adjunctive low\u2010level laser therapy appears feasible and may improve early postoperative outcomes following periodontal flap surgery. Larger randomized trials are required to confirm these findings.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n The study was prospectively registered with the Clinical Trials Registry\u2013India (CTRI\/2025\/09\/095379) on September 24, 2025.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lsm.70133","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:51:08Z","timestamp":1776318668000},"page":"418-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cyanoacrylate Adhesive With Low\u2010Level Laser Therapy for Sutureless Periodontal Flap Closure: A Pilot Randomized Controlled Trial"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7647-7030","authenticated-orcid":false,"given":"Kratee","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Periodontics, Teerthanker Mahaveer Dental College and Research Centre Teerthanker Mahaveer University Moradabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1077-984X","authenticated-orcid":false,"given":"Shalabh","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Teerthanker Mahaveer Dental College and Research Centre Teerthanker Mahaveer University Moradabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14050456"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2022.02.005"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.1.34"},{"issue":"5","key":"e_1_2_15_5_1","first-page":"95","article-title":"Comparison Between Silk Sutures and Cyanoacrylate Adhesive in Human Mucosa: A Clinical and Histological Study","volume":"5","author":"Kumar M. S.","year":"2013","journal-title":"Journal of International Oral Health"},{"issue":"63","key":"e_1_2_15_6_1","first-page":"253","article-title":"Comparative Evaluation of n\u2010Butyl Cyanoacrylate and Silk Sutures on Healing of Periodontal Flaps: A Clinico\u2010Histological Evaluation","volume":"16","author":"Saquib A. 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