{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:05:16Z","timestamp":1784304316052,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81172590"],"award-info":[{"award-number":["81172590"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrophic acne scars are a common sequela of inflammatory acne, resulting from abnormal dermal remodeling due to imbalance in collagen synthesis and degradation. Laser therapies, including picosecond and fractional lasers, have emerged as effective treatments, yet direct comparative studies remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the efficacy, safety, and tolerability of 1064\u2010nm microlens array picosecond laser (P\u2010MLA) versus 1927\u2010nm sub\u2010ablative fractional thulium laser (FTL) in Asian patients with atrophic acne scars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, single\u2010center, evaluator\u2010blinded, randomized trial employed a split\u2010face design. Thirty\u2010five patients with symmetric facial atrophic acne scars received three sessions of P\u2010MLA on one side and FTL on the contralateral side at 4\u2010week intervals. Clinical outcomes were assessed using ECCA scores and blinded physician GAIS. Objective skin parameters (TEWL, MI, and EI) were measured, and patient satisfaction and adverse events were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both lasers significantly improved ECCA scores compared to baseline (P\u2010MLA: 102.86\u2009\u00b1\u200947.47\u2009\u2192\u200986.86\u2009\u00b1\u200947.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; FTL: 101.43\u2009\u00b1\u200944.89\u2009\u2192\u200985.57\u2009\u00b1\u200950.54,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with no significant difference between sides. GAIS score was significantly higher on the P\u2010MLA side (2.83\u2009\u00b1\u20091.272 vs. 2.57\u2009\u00b1\u20091.243,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037). P\u2010MLA demonstrated lower MI and EI at 3 months post\u2010treatment, reduced intraoperative pain, shorter crusting duration, and minimal social downtime, whereas FTL exhibited higher crusting and erythema. TEWL returned to baseline for both groups. Patient satisfaction was high and comparable between sides.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both P\u2010MLA and FTL are effective for treating atrophic acne scars in Asian patients, demonstrating comparable clinical efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70134","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:44:59Z","timestamp":1776318299000},"page":"447-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy and Safety of 1064\u2010nm Picosecond Laser and 1927\u2010nm Fractional Thulium Laser for Atrophic Acne Scars in Asian Patients: A Prospective, Randomized, Split\u2010Face Study"],"prefix":"10.1002","volume":"58","author":[{"given":"Kai","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0245-6431","authenticated-orcid":false,"given":"Luyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1016-6392","authenticated-orcid":false,"given":"Dan","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9274-4527","authenticated-orcid":false,"given":"Yu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiliu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aesthetic Medicine, Xi'an Honghui Hospital Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2679-5695","authenticated-orcid":false,"given":"Zhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8374-7852","authenticated-orcid":false,"given":"Weihui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/893080"},{"issue":"6","key":"e_1_2_10_3_1","article-title":"The Use of a Fractional Laser in Acne Scar Treatment\u2010A Systematic Review","volume":"15","author":"Ptaszek B.","year":"2025","journal-title":"Life 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