{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:32:01Z","timestamp":1786559521391,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103764"],"award-info":[{"award-number":["82103764"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515010143"],"award-info":[{"award-number":["2020A1515010143"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adipose\u2010derived stem cells treated with low\u2010level laser light (LLLT\u2010ADSCs) demonstrate an inhibitory effect on keloid scars, although the underlying molecular mechanisms remain largely unknown. This study aims to elucidate these mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated the morphology, quantity, and microRNA (miRNA) expression profiles of exosomes derived from LLLT\u2010ADSCs compared to those from untreated ADSCs. Notably, hsa\u2010miR\u201026a\u20105p was found to be highly expressed in exosomes from LLLT\u2010ADSCs. We examined its impact on the proliferation, migration, and invasion of keloid fibroblasts (KFs) by modulating its expression levels in these cells. A dual\u2010luciferase reporter assay was utilized to confirm the interaction between hsa\u2010miR\u201026a\u20105p and the Jagged\u20101\/Notch signaling pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant variations were observed in the exosomal contents between LLLT\u2010ADSCs and ADSCs. Enhanced expression of hsa\u2010miR\u201026a\u20105p was associated with reduced proliferation, migration, and invasion of KFs, along with diminished expression of Jagged\u20101 and NICD proteins. Conversely, suppression of hsa\u2010miR\u201026a\u20105p expression reversed these effects. The dual\u2010luciferase reporter system demonstrated that modifications in the binding sites of Jag\u20101 significantly mitigated the downregulation of Jag\u20101 expression induced by miRNA interaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LLLT\u2010ADSCs can produce and deliver hsa\u2010miR\u201026a\u20105p via exosomes to suppress the Jagged\u20101\/Notch pathway activation in KFs, thereby effectively preventing the progression of keloid scars. This mechanism presents a novel therapeutic strategy for managing keloid scars.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70135","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T17:05:22Z","timestamp":1779815122000},"page":"564-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LLLT\u2010ADSCs Curtail the Progression of Keloid Through Exosomal miR\u201026a\u20105p Downregulating Jag\/Notch Pathway"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2207-672X","authenticated-orcid":false,"given":"Bing","family":"Han","sequence":"first","affiliation":[{"name":"Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, The Scar and Wound Treatment Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetic Center, Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwen","family":"Bai","sequence":"additional","affiliation":[{"name":"Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, The Scar and Wound Treatment Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Jiao","sequence":"additional","affiliation":[{"name":"Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, The Scar and Wound Treatment Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Mian Ning Country Hospital Of TCM Mianning City Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5361-9080","authenticated-orcid":false,"given":"Jun","family":"Shi","sequence":"additional","affiliation":[{"name":"Guangzhou Higher Education Mega Center, School of Chinese Materia Medica Guangdong Pharmaceutical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Department of Burn and Plastic Surgery, Guangzhou Red Cross Hospital Jinan University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13203"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041245"},{"key":"e_1_2_12_4_1","first-page":"48","article-title":"The Pathophysiology and Management of Pathologic Scarring: A Contemporary Review","volume":"14","author":"Sophia G. H.","year":"2024","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S446018"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122623"},{"issue":"5","key":"e_1_2_12_7_1","first-page":"607","article-title":"Shining Light on Nanotechnology to Help Repair and Regeneration","volume":"31","author":"Asheesh G.","year":"2012","journal-title":"Biotechnol Adv"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.114036"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6664627"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S448667"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2567-9"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.92897"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkad036"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1247734"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001138"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28281"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0786-4"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-024-03912-z"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000007591"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2021.105921"},{"key":"e_1_2_12_21_1","first-page":"2926","article-title":"Characteristics of the Dynamic Evolutionary Pathway of ADSCs Induced Differentiation Into Astrocytes Based on scRNA\u2010Seq Analysis","volume":"62","author":"Xiaodong Y.","year":"2024","journal-title":"Molecular Neurobiology"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-024-03871-z"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03345-0"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1374715"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.133622"},{"key":"e_1_2_12_26_1","first-page":"1","article-title":"Adipose\u2010Derived Mesenchymal Stem Cells Promote Liver Regeneration and Suppress Rejection in Small\u2010for\u2010size Liver Allograft","volume":"45","author":"Wei G.","year":"2017","journal-title":"Transplant Immunolog"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e11495"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-016-0356-6"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2024.08.010"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16509"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.10.073"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179176"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-015-0524-6"},{"key":"e_1_2_12_34_1","article-title":"Red and Near\u2010infrared Light Evokes Ca(2+) Influx, Endoplasmic Reticulum Release and Membrane Depolarization in Neurons and Cancer Cells","volume":"214","author":"Iuliia G.","year":"2020","journal-title":"Journal of Photochemistry and Photobiology B: Biology"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-024-04008-z"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14081"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/irab116"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02517-0"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02290-0"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.207"},{"issue":"5","key":"e_1_2_12_41_1","first-page":"4332","article-title":"MicroRNA\u201026a Inhibits Hyperplastic Scar Formation by Targeting Smad2","volume":"15","author":"Jun Q.","year":"2018","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-025-01667-9"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.09.001"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2012.00823.x"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs269"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.134742"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0455-y"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.942446"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.70135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:09:15Z","timestamp":1786558155000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.70135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/lsm.70135"],"URL":"https:\/\/doi.org\/10.1002\/lsm.70135","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"2025-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}