{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:00:52Z","timestamp":1784696452475,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non\u2010surgical treatment of the aging lower face remains a therapeutic challenge. Tissue Micro\u2010Coring Technology (MCT) is a novel technology that permits the non\u2010surgical removal of skin as micro\u2010cores, tightening skin and inducing collagen and elastin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate safety and efficacy of MCT for the treatment of the aging lower face.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, single\u2010site study assessed outcomes for subjects treated with MCT. Assessments included the change from baseline in Lemperle Wrinkle Severity Scale (LWSS) assessed for the nasolabial folds (NLF), marionette lines, lip lines, and global esthetic improvement scale (I\u2010GAIS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 10 patients met the study criteria. Mean (SD) I\u2010GAIS was 1.7 (0.36), and mean (SD) change from baseline in LWSS for NLF, marionette lines, and lip lines were 1.1 (0.46), 1.3 (0.3), and 0.6 (0.35), respectively. Most subjects had some improvement in LWSS across all three treatment areas, with many experiencing &gt;\u20091\u2010point improvements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Limitations include the retrospective study design, small study population, and single\u2010sex population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the real\u2010world setting, MCT leads to improvements in global appearance and wrinkle severity. MCT is an effective alternative to injectable fillers for the treatment of nasolabial fold and marionette and perioral lines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70143","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T21:05:21Z","timestamp":1777842321000},"page":"474-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tissue Micro\u2010Coring Is a Safe and Effective Option for the Treatment of the Nasolabial Fold, Marionette, and Perioral Rhytids"],"prefix":"10.1002","volume":"58","author":[{"given":"Omar A.","family":"Ibrahimi","sequence":"first","affiliation":[{"name":"Connecticut Skin Institute Stamford Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew M.","family":"Avram","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Ray","family":"Jalian","sequence":"additional","affiliation":[{"name":"Private Practice Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazanin","family":"Saedi","sequence":"additional","affiliation":[{"name":"Dermatology Associates of Plymouth Meeting Plymouth Meeting  Pennsylvania USA"},{"name":"Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjaa339"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.2357"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/gox.0000000000004547"},{"key":"e_1_2_11_5_1","unstructured":"US Food and Drug Administration. Updated July 12 2022 accessed September 11 2023.https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf20\/K202517.pdf."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/gox.0000000000003905"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200111000-00048"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/ccid.S296970"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpsam.2022.0319"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjab304"},{"key":"e_1_2_11_11_1","unstructured":"J. S.WaibelEffectiveness of Dermal Micro\u2010Coring Technology (MCT) For Minimally\u2010Invasive Skin Tightening: Interim Results and Gene Expression Analysis. Abstract presented at: American Society for Dermatologic Surgery Annual Meeting; November 2\u20105 2023; Chicago IL."}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.70143","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:20:35Z","timestamp":1784301635000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.70143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,3]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/lsm.70143"],"URL":"https:\/\/doi.org\/10.1002\/lsm.70143","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,3]]},"assertion":[{"value":"2025-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}