{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:31:59Z","timestamp":1786559519827,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the efficacy and safety of fractional carbon dioxide (CO\n                      <jats:sub>2<\/jats:sub>\n                      ) laser therapy in women with vulvar lichen simplex chronicus (VLSC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study included 88 women with VLSC who underwent three sessions of fractional CO\n                      <jats:sub>2<\/jats:sub>\n                      laser treatment between January 2022 and January 2024. Clinical outcomes were assessed using the Cattaneo clinical symptom and sign scoring system to calculate the therapeutic efficacy index. Vulvar pruritus and dyspareunia were evaluated using a visual analog scale (VAS), and patient\u2010reported global improvement was assessed with the Patient Global Impression of Change (PGI\u2010C) questionnaire. Follow\u2010up assessments were conducted at 1, 6, and 12 months after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 1, 6, and 12 months post\u2010treatment, significant reductions were observed in VAS scores for vulvar pruritus and dyspareunia, as well as in Cattaneo clinical symptom and sign scores (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The overall response rates were 89.8% (79\/88; 95% confidence interval [CI], 81.7%\u201394.5%), 93.2% (82\/88; 95% CI, 85.9%\u201396.8%), and 88.6% (78\/88; 95% CI, 80.3%\u201393.7%), respectively. According to the PGI\u2010C questionnaire, the proportions of patients reporting improvement or marked improvement were 72.7%, 78.4%, and 70.5% at the corresponding follow\u2010up time points. No significant differences in treatment outcomes were observed according to disease duration or menopausal status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Fractional CO\n                      <jats:sub>2<\/jats:sub>\n                      laser therapy was associated with significant and sustained improvement in clinical symptoms and signs of VLSC, suggesting that it may represent a promising therapeutic option for selected women with VLSC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70148","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:26:31Z","timestamp":1778851591000},"page":"516-523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Fractional Carbon Dioxide Laser Treatment in Women With Vulvar Lichen Simplex Chronicus: A Retrospective Study With 12\u2010Month Follow\u2010Up"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6724-2125","authenticated-orcid":false,"given":"Nengxiu","family":"Wu","sequence":"first","affiliation":[{"name":"Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics Fujian Medical University Fuzhou Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siai","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics Fujian Medical University Fuzhou Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4631-0218","authenticated-orcid":false,"given":"Chaoqin","family":"Lin","sequence":"additional","affiliation":[{"name":"Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics Fujian Medical University Fuzhou Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3175-2881","authenticated-orcid":false,"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics Fujian Medical University Fuzhou Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000001054"},{"issue":"1","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/AOG.0000000000003944","article-title":"Diagnosis and Management of Vulvar Skin Disorders: ACOG Practice Bulletin No. 224","volume":"136","author":"American College of Obstetricians and Gynecologists","year":"2020","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-025-00979-z"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1708856"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003646"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-23-677"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462414554271"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14096"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2021.0053"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-023-06300-7"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-022-03180-5"},{"issue":"4","key":"e_1_2_13_13_1","first-page":"301","article-title":"Lichen Sclerosus and Squamous Hyperplasia of the Vulva. A Clinical Study of Medical Treatment","volume":"36","author":"Cattaneo A.","year":"1991","journal-title":"Journal of Reproductive Medicine"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.919135"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000700"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2014.12.006"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-014-1677-2"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000004809"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.70099"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2022.10.017"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004409"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23476"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004332"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001727"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/gmit.gmit_71_24"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.70148","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:09:09Z","timestamp":1786558149000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.70148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/lsm.70148"],"URL":"https:\/\/doi.org\/10.1002\/lsm.70148","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]},"assertion":[{"value":"2025-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}