{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:31:59Z","timestamp":1786559519819,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Benign prostatic hyperplasia (BPH) with median\u2010lobe enlargement (MLE) is a distinct and challenging clinical entity contributing to lower urinary tract symptoms (LUTS). Minimally invasive treatments, such as transperineal laser ablation (TPLA), offer potential advantages in treating this subgroup, but limited data exist regarding their outcomes. The aim of this study is to evaluate the efficacy and safety of EchoLaser TPLA of symptomatic BPH with MLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study retrospectively evaluated 31 patients with symptomatic BPH and MLE who underwent EchoLaser TPLA at a private clinic. EchoLaser TPLA was performed with a proprietary 1064\u2010nm continuous\u2010wave diode laser. Baseline and 6\u2010month follow\u2010up assessments included International Prostate Symptom Score (IPSS), quality of life (QoL), prostate volume (PV), postvoid residual (PVR), peak urinary flow rate (Q\n                      <jats:sub>max<\/jats:sub>\n                      ), and International Index of Erectile Function (IIEF\u201015). Safety outcomes were categorized using the Clavien\u2013Dindo classification system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EchoLaser TPLA significantly improved IPSS (median 22 to 6.5;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), QoL (median 5 to 1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), PV (median 105\u2009mL to 43\u2009mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), PVR (median 120\u2009mL to 23.5\u2009mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and Q\n                      <jats:sub>max<\/jats:sub>\n                      (median 7.6\u2009mL\/s to 15.95\u2009mL\/s;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at 6 months. IIEF\u201015 scores remained stable, indicating preservation of erectile function. No intraoperative adverse events occurred; two mild periprocedural events (urinary tract infection, hematuria) were successfully managed conservatively. Nine of 10 catheter\u2010dependent patients resumed normal voiding.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EchoLaser TPLA is an effective and safe minimally invasive treatment for BPH with MLE, offering significant symptomatic relief, functional improvement, and a favorable safety profile while preserving sexual function. These findings position EchoLaser TPLA as a promising alternative to conventional treatments for this challenging patient subgroup.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70149","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T18:35:26Z","timestamp":1779129326000},"page":"524-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transperineal Laser Ablation of Symptomatic Benign Prostatic Hyperplasia With Median\u2010Lobe Enlargement: A Single\u2010Center Experience"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0588-0241","authenticated-orcid":false,"given":"Antonio","family":"Ruffo","sequence":"first","affiliation":[{"name":"Department of Medicine and Health Sciences ''V. Tiberio'' University of Molise Campobasso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Stanojevic","sequence":"additional","affiliation":[{"name":"Urogenital Center Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Crocetto","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Reproductive Sciences and Odontostomatology University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-132X","authenticated-orcid":false,"given":"Biagio","family":"Barone","sequence":"additional","affiliation":[{"name":"Department of Urology Ospedale San Paolo, ASL NA1 Naples Centro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Holy","sequence":"additional","affiliation":[{"name":"Urosante Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo Maria","family":"Altieri","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences ''V. Tiberio'' University of Molise Campobasso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1175-8637","authenticated-orcid":false,"given":"Lorenzo","family":"Spirito","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialized Surgery, Unit of Urology University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Esposito","sequence":"additional","affiliation":[{"name":"Casa di Cura Nostra Signora di Lourdes Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06628-8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002183"},{"key":"e_1_2_12_4_1","unstructured":"J. N.Cornu D.Elterman H.Hashim et al. \u201cEAU Guidelines on Non\u2010neurogenic Male Lower Urinary Tract Symptoms (LUTS) \u201dhttps:\/\/d56bochluxqnz.cloudfront.net\/documents\/full-guideline\/EAU-Guidelines-on-Non-Neurogenic-Male-LUTS-2026.pdf(2026 accessed 26 March2026)."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.4111\/icu.2019.60.5.333"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/15579883221113203"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562872231198634"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.16008"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-023-03717-8"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2024.04.023"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.08.018"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-021-03685-7"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bco2.278"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36966-5"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00238-0"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-017-1662-9"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-019-0196-4"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003698"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.10.181"},{"issue":"12","key":"e_1_2_12_20_1","first-page":"1925","article-title":"Transperineal Laser Ablation of the Prostate: Mri\u2011Based Assessment of the Ablation Cavity and Correlation With Clinical Outcomes","volume":"44","author":"Manenti G.","year":"2021","journal-title":"Cardiovascular and Interventional Radiology"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-018-0118-x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-5538.IBJU.2025.0423"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-025-00972-x"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jsxmed\/qdaf150"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.70149","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:09:07Z","timestamp":1786558147000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.70149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/lsm.70149"],"URL":"https:\/\/doi.org\/10.1002\/lsm.70149","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"assertion":[{"value":"2026-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}