{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:57:55Z","timestamp":1790434675469,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to investigate the safety and efficacy of high\u2010intensity, non\u2010focused, parallel ultrasound treatments to lift lax tissue in the submental and neck zones, lift the eyebrow, and improve facial wrinkles in an Asian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, open\u2010label, non\u2010randomized single\u2010center, self\u2010controlled clinical study recruited 42 participants aged 35 to 67. Participants received a single treatment, covering the full face, neck, and submental zones. Standardized images were taken, and assessments were performed using the Physician Global Aesthetic Improvement Scale (PGAIS) and Fitzpatrick Classification of Wrinkling and Degree of Elastosis. 3D images were taken to calculate the volume change after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 42 patients, 83.3% showed improvement in submental and neck skin laxity at the 3\u2010month follow\u2010up. Improvements were also observed in eyebrow elevation (28.6%) and facial wrinkles (38.1%) at 3 months. The Fitzpatrick Wrinkle and Elastosis Scale showed improvement in 26.2% of patients at 3 months, with sustained effects up to 9 months in 12.8% of patients. A trend of volumetric reduction of 1.04\u2009\u00b1\u20093.49\u2009ml (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06) was demonstrated in the jawline and submental area. Transient edema and erythema were noted in 7.2% and 50% of patents initially but resolved on subsequent follow\u2010up visits, and no other adverse events were documented.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High\u2010intensity, non\u2010focused, parallel ultrasound is effective in improving skin laxity and facial wrinkles in Asian patients, with minimal side effects and good tolerability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70153","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:35:51Z","timestamp":1780378551000},"page":"637-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Use of High\u2010Intensity Non\u2010Focused Ultrasound Treatment to Improve Skin Laxity and Facial Wrinkles in Asian Patients"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9420-4667","authenticated-orcid":false,"given":"Martin M. H.","family":"Chung","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4603-6407","authenticated-orcid":false,"given":"Christina S. M.","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy W. M.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha Y. N.","family":"Shek","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9254-1554","authenticated-orcid":false,"given":"C. K.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry H. L.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine The University of Hong Kong Hong Kong SAR China"},{"name":"Wellman Centre for Photomedicine, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21070"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20731"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2016.1435"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.724534"},{"issue":"3","key":"e_1_2_7_6_1","first-page":"259","article-title":"Skin Rejuvenation and Wrinkle Reduction Using a Fractional Radiofrequency System","volume":"8","author":"Hruza G.","year":"2009","journal-title":"Journal of Drugs in Dermatology: JDD"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2023.05.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16098"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000004240"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16670"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23771"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003809"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003767"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15672"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003208"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjaf053"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22768"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-023-01078-9"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2010.00574.x"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.70153","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:01:52Z","timestamp":1790431312000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.70153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/lsm.70153"],"URL":"https:\/\/doi.org\/10.1002\/lsm.70153","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"2025-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}