{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:57:58Z","timestamp":1790434678518,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinicians frequently use diode laser\u2010assisted oral frenectomy to correct anatomical restrictions in the oral cavity as a minimally invasive alternative. However, evidence for its effect on wound healing and on reducing common postoperative complications remains unclear. This systematic review and meta\u2010analysis aimed to evaluate the clinical efficacy of diode laser\u2010assisted frenectomy compared with the conventional scalpel technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This review adheres to the PRISMA statement, and the protocol is registered in PROSPERO (CRD420251050170). A comprehensive electronic and manual search identified comparative studies of diode laser vs. scalpel frenectomy from January 2015 to December 2025. The analysis pooled the primary outcomes (postoperative discomfort, intraoperative hemorrhage, and wound healing) with 95% confidence intervals (CI) using a random\u2010effects model. Heterogeneity assessment used the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistic. Visual inspection of funnel\u2010plot symmetry assessed publication bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fourteen studies met the inclusion criteria. The meta\u2010analysis showed that the diode laser reduced postoperative pain on day 1 (SMD\u2009=\u2009\u22121.73; 95% CI: \u22122.70 to \u22120.77) and day 7 (SMD\u2009=\u2009\u22121.84; 95% CI: \u22122.78 to \u22120.90), compared with the scalpel. The diode laser also reduced intraoperative hemorrhage (SMD\u2009=\u2009\u20131.97; 95% CI: \u22122.89 to \u22121.05). Wound healing on day 7 did not differ significantly between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta\u2010analysis indicates that diode laser\u2010assisted frenectomy reduces postoperative pain, significantly. In addition, the laser group experienced less intraoperative hemorrhage and better wound healing at 7 day. Future clinical trials should standardize wound\u2010healing indices, define uniform follow\u2010up intervals, and incorporate cost\u2010effectiveness analyses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70156","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T18:21:12Z","timestamp":1781547672000},"page":"604-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diode Laser\u2010Assisted Oral Frenectomy as a Modern Alternative: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0847-7076","authenticated-orcid":false,"given":"Zahra","family":"Baghani","sequence":"first","affiliation":[{"name":"Department of Periodontics, Faculty of Dentistry Sabzevar University of Medical Sciences Sabzevar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0259-9827","authenticated-orcid":false,"given":"Pouria","family":"Soltaninezhad","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Sabzevar University of Medical Sciences Sabzevar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Assarzadeh","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Faculty of Dentistry Sabzevar University of Medical Sciences Sabzevar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pegah","family":"Sadeghnezhad","sequence":"additional","affiliation":[{"name":"Department of Dentistry Mashhad University of Medical Science Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.107467"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2017.06.018"},{"key":"e_1_2_8_4_1","volume-title":"Frenectomy for the Correction of Ankyloglossia: A Review of Clinical Effectiveness and Guidelines","author":"CAf D.","year":"2016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2020.03.026"},{"issue":"9","key":"e_1_2_8_6_1","first-page":"1587","article-title":"Frenectomy: A Review With the Reports of Surgical Techniques","volume":"6","author":"Devishree G. 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