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The model included a single 20\u2009Gy focal irradiation dose to the left mandible, followed by the first mandibular molar extraction 10 days later. During the experiment, some animals were lost due to procedural causes unrelated to treatment, resulting in final group sizes of 5, 5, 3, 4, and 6, respectively. The results were evaluated by micro\u2010computed tomography (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02), radiographic examinations, histopathological analysis, and assessment of hepatic steatosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Irradiated untreated animals showed the most pronounced structural and histopathological alterations. All treatment protocols improved bone repair compared with the irradiated untreated group. However, the combined protocol consistently showed the most favorable structural, radiographic, and histological findings, with better preservation of bone architecture and more organized osteogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>aPDT combined with systemic pharmacological therapy may represent a promising multimodal strategy for irradiated mandibular bone injury relevant to ORN development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70163","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:25:22Z","timestamp":1781634322000},"page":"683-692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antimicrobial Photodynamic Therapy Associated With Systemic Treatment in Osteoradionecrosis: An In Vivo 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8222-7131","authenticated-orcid":false,"given":"Cristina Paix\u00e3o","family":"Dur\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Dentistry Montes Claros State University (Unimontes) Montes Claros Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5267-3137","authenticated-orcid":false,"given":"Renata Sousa","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Dentistry Montes Claros State University (Unimontes) Montes Claros Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9383-0039","authenticated-orcid":false,"given":"Ludmila Martins","family":"Delazeri","sequence":"additional","affiliation":[{"name":"Department of Dentistry Montes Claros State University (Unimontes) Montes Claros Minas Gerais 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