{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:19:33Z","timestamp":1791487173924,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report the first case of Koebner phenomenon induced by picosecond laser treatment in a patient with psoriasis. We analyzed the clinical and histopathological features and discussed the possible mechanism by which the laser's photomechanical effect triggered the reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A 58\u2010year\u2010old woman with well\u2010controlled plaque psoriasis underwent 755\u2010nm picosecond alexandrite laser treatment (pulse duration: 750\u2009ps; fluence: 3.77\u2009J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ; spot size: 3\u2009mm) for seborrheic keratoses on the back and lower waist. Clinical, dermoscopic, and histopathological assessments were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One month after treatment, erythematous, scaly plaques emerged at the laser\u2010irradiated sites. Clinical and dermoscopic findings were consistent with psoriasis. Histology confirmed psoriasiform changes, and immunohistochemistry demonstrated a T\u2010cell\u2013predominant infiltrate (CD3\n                      <jats:sup>+<\/jats:sup>\n                      ) with dermal CD4\n                      <jats:sup>+<\/jats:sup>\n                      predominance and epidermal CD8\n                      <jats:sup>+<\/jats:sup>\n                      enrichment. Notably, no Koebner phenomenon was seen in coexisting melanocytic nevi. Lesions resolved after 4 weeks of topical corticosteroids, with no recurrence up to 4 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>To our knowledge, this is the first report of the Koebner phenomenon induced by picosecond laser therapy in a patient with psoriasis. Although picosecond lasers are known for minimal thermal damage, their photomechanical effects may activate immune responses and trigger new psoriatic lesions. Therefore, caution and careful monitoring are advised when using picosecond lasers in patients with psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70171","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:16:19Z","timestamp":1782857779000},"page":"745-749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Triggering of Koebner Phenomenon by Picosecond Laser in a Psoriatic Patient: Clinical and Immunopathologic Insights"],"prefix":"10.1002","volume":"58","author":[{"given":"Teppei","family":"Sakai","sequence":"first","affiliation":[{"name":"SAKAI CLINIC, Yoshiimachi, Ukihashi Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koya","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Setagaya Sonoda Dermatology Clinic, Setagaya, Setagaya\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-4804","authenticated-orcid":false,"given":"Jun","family":"Omatsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine, Hongo, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22820"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdrv.2025.06.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000104261"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14709"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1990.tb03821.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1982.tb02070.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020434"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2020.07.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.04.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.04.09"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60071177"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001263"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.25289\/ML.2020.9.1.62"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000663"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.70171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:35:37Z","timestamp":1791484537000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.70171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/lsm.70171"],"URL":"https:\/\/doi.org\/10.1002\/lsm.70171","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"assertion":[{"value":"2025-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}