{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:19:32Z","timestamp":1791487172684,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effects of laser photobiomodulation (PBM) using the systemic vascular technique (VPBM) on glycemic control in individuals with type 2 diabetes mellitus (T2DM) undergoing conventional pharmacological treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective single\u2010arm clinical study was conducted at Centro Universit\u00e1rio UNITOP, in Palmas, Tocantins, Brazil. Individuals diagnosed with T2DM who had been receiving continuous oral hypoglycemic therapy with metformin (500\u2009mg to 850\u2009mg) for at least 6 months were included. PBM was applied transcutaneously over the radial artery using a low\u2010level laser device emitting red light, aiming to promote systemic vascular irradiation. Capillary blood glucose levels were monitored through self\u2010monitoring, while fasting plasma glucose and glycated hemoglobin (HbA1c) levels were analyzed in a certified clinical laboratory throughout the follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In type 2 diabetes patients, VPBM induced significant acute reductions in capillary blood glucose immediately after all sessions (from averages over 180\u2013220\u2009mg\/dL down to 119\u2013129\u2009mg\/dL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.0019). It also significantly lowered baseline fasting blood glucose over the 6\u2010week protocol from 161.40\u2009\u00b1\u200932.63\u2009mg\/dL to 130.40\u2009+\u200937.62\u2009mg\/dL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0339). However, it showed no statistically significant effects on HbA1c: 7.61% to 7.65% or systolic blood pressure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Systemic application of low\u2010level laser therapy through the vascular technique, combined with standard oral hypoglycemic therapy, may contribute to improved glycemic control in individuals with T2DM. PBM associated with VPBM appears to represent a promising complementary therapeutic strategy for metabolic management in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70192","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:16:51Z","timestamp":1787203011000},"page":"778-785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Vascular Photobiomodulation on Glycemic Control in Patients With Type II Diabetes Mellitus: A Prospective Single\u2010Arm Clinical Study"],"prefix":"10.1002","volume":"58","author":[{"given":"Leandro Augusto","family":"Almeida","sequence":"first","affiliation":[{"name":"Postgraduate Program in Biomedical Engineering Universidade Brasil S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1332-2619","authenticated-orcid":false,"given":"Anne","family":"Missrie","sequence":"additional","affiliation":[{"name":"Faculdade Israelita de Ci\u00eancias da Sa\u00fade Albert Einstein S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8112","authenticated-orcid":false,"given":"Victor Augusto Ramos","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biomedical Engineering Universidade Brasil S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0392-700X","authenticated-orcid":false,"given":"Patricia","family":"Brassolatti","sequence":"additional","affiliation":[{"name":"Department of Research and Innovation IBRAMED Amparo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-7180","authenticated-orcid":false,"given":"Ana Laura Martins","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biomedical Engineering Universidade Brasil S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Faculdade Israelita de Ci\u00eancias da Sa\u00fade Albert Einstein S\u00e3o Paulo S\u00e3o Paulo 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