{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:28:15Z","timestamp":1787578095823,"version":"build-2736575974"},"reference-count":81,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Laser and light\u2010based therapies are widely used in dermatology, yet patients with inflammatory dermatoses are often excluded from cosmetic procedures due to concerns for disease exacerbation. This systematic review evaluated the safety and efficacy of these modalities to inform their use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A PRISMA\u2010guided search of PubMed, Embase, ClinicalTrials.gov, and Scopus from inception through March 1, 2026 identified studies of adults with psoriasis, atopic dermatitis, lichen sclerosus, lichen planus pigmentosus, frontal fibrosing alopecia, or cutaneous sarcoidosis treated with laser or light\u2010based therapies. Eligible studies reported clinical outcomes and adverse events; reviews and studies without attributable outcomes were excluded. Risk of bias was assessed qualitatively, and results were synthesized descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010seven studies including over 900 patients were analyzed, with the strongest evidence in psoriasis and lichen sclerosus. Across conditions and device types, therapies consistently demonstrated clinical improvement and were generally well tolerated. Adverse effects were predominantly localized and transient, including erythema, edema, blistering, and pigmentary changes. Serious adverse events were rare, with only isolated cases of koebnerization or disease worsening reported. Limitations include heterogeneity and predominance of small or non\u2010randomized studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that, in appropriately selected patients, laser and light\u2010based therapies are safe and do not consistently precipitate disease exacerbation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70198","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T12:53:01Z","timestamp":1787575981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laser and Light\u2010Based Therapies in Inflammatory Dermatoses: A Systematic Review of Safety, Efficacy, and Adverse Effects to Inform Cosmetic Use"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2280-9791","authenticated-orcid":false,"given":"Carli","family":"Tucci","sequence":"first","affiliation":[{"name":"New York University Grossman School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Li","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Ettefa","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-3817","authenticated-orcid":false,"given":"Maressa C.","family":"Criscito","sequence":"additional","affiliation":[{"name":"The Ronald O. 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