{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:44:47Z","timestamp":1793119487205,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The primary objective was to evaluate the long\u2010term recurrence rate following RCM\u2013OCT\u2010guided laser ablation of basal cell carcinomas (BCCs). The secondary objective was to assess patient\u2010reported outcomes, including willingness to undergo the treatment again, scar acceptability, and adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort study evaluated 104 patients with 148 BCCs (2017\u20132021). Low risk BCC subtypes and with tumor depth of \u2264\u2009300\u2009\u00b5m were determined using RCM\u2013OCT, and eligible lesions underwent same\u2010day Er:YAG laser ablation with immediate post\u2010treatment imaging to confirm clearance. Patients underwent clinical and RCM\u2013OCT or RCM surveillance at 6 and 12 months and annually thereafter to assess recurrence. A patient\u2010reported questionnaire was conducted in 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010eight lesions (39.2%) in 39 patients met the criteria for laser ablation. Most lesions were located on the trunk (29\/58, 50.0%), with median tumor depth and lesion size of 200\u2009\u00b5m and 9.8\u2009mm, respectively. Immediate post\u2010ablation RCM\u2013OCT demonstrated imaging\u2010defined complete clearance after a single session in 53\/58 lesions (91.4%). Residual tumors (5\/58, 8.6%) were successfully treated during the same visit. Fifty\u2010four of 58 lesions (93.1%) had at least 6 months of follow\u2010up (median 32 months; min\/max 8\u201370). One recurrence occurred at 53 months and was successfully retreated, corresponding to 1.04 recurrences per 100 person\u2010years of follow\u2010up. The patient\u2010reported questionnaire response rate was 79.5% (31\/39). Overall, 96.8% (30\/31) reported acceptable scar appearance, 83.9% (26\/31) were likely to choose laser ablation again (Score 1\u20132 of 5), and 9.7% (3\/31) reported mild, transient side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RCM\u2013OCT\u2010guided Er:YAG laser ablation offers a \u201cone\u2010stop\u201d treatment approach for selected low\u2010risk BCCs, demonstrating low long\u2010term recurrence rates and high patient satisfaction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70201","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:27:06Z","timestamp":1787758026000},"page":"786-795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reflectance Confocal Microscopy\u2013Optical Coherence Tomography\u2010Guided Laser Ablation of Low\u2010Risk Basal Cell Carcinoma: A Long\u2010Term Prospective Follow\u2010Up Study"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9533-6222","authenticated-orcid":false,"given":"Noa","family":"Kremer","sequence":"first","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Department of Dermatology, Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2962-0671","authenticated-orcid":false,"given":"Miguel","family":"Cordova","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dermatology Service Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dermatology Service Memorial 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