{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:12:07Z","timestamp":1788797527498,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The 675\u2010nm diode laser has emerged as a novel wavelength for non\u2010ablative skin rejuvenation, with potential advantages in selective dermal targeting and minimal epidermal injury. However, integrated clinical and biologic evidence across multiple esthetic domains remains limited. This study aimed to evaluate the efficacy and safety of high\u2010powered 675\u2010nm laser treatment for facial rejuvenation in a real\u2010world clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this prospective single\u2010center study, 22 adults with facial erythema, fine wrinkles, enlarged pores, and textural irregularities underwent 3 monthly sessions of 675\u2010nm non\u2010ablative diode laser treatment. Objective outcomes were assessed using three\u2010dimensional imaging at baseline and the 3\u2010month follow\u2010up (T3). Blinded Global Esthetic Improvement Scale (GAIS) evaluations were performed for pigmentation and erythema. An exploratory histologic analysis was conducted in a subset of participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighteen participants completed the paired imaging analysis. Significant improvements were observed in wrinkle (+0.73\u2009\u00b1\u20090.86,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), pore (+1.54\u2009\u00b1\u20092.24,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010), and smoothness scores (+2.18\u2009\u00b1\u20092.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), with large effect sizes (Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>z<\/jats:italic>\n                      <\/jats:sub>\n                      0.69\u20130.93). Blinded GAIS assessments demonstrated \u2265\u200950% improvement in 61.1% of participants for both pigmentation and erythema. Treatment\u2010related pain was mild (median visual analog scale score: 2.0), and no serious adverse events or post\u2010inflammatory hyperpigmentation were observed. Histologic findings suggested increased dermal collagen components.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High\u2010powered 675\u2010nm non\u2010ablative diode laser treatment significantly improved objective skin texture parameters and provided clinically perceptible improvements in pigmentation and erythema, with favorable tolerability. These findings support its role as a versatile and effective modality for comprehensive facial rejuvenation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70204","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:01:15Z","timestamp":1788796875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Efficacy and Histologic Correlation of a High\u2010Powered 675\u2010nm Non\u2010Ablative Diode Laser for Facial Rejuvenation"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1299-6883","authenticated-orcid":false,"given":"Ye Ji","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medicine, Hallym University Sacred Heart Hospital Anyang Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Bundang Renewme Skin Clinic Seongnam Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6562-5385","authenticated-orcid":false,"given":"Seongjun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine, Hallym University Sacred Heart Hospital Anyang Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8505-9794","authenticated-orcid":false,"given":"Dongwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine, Hallym University Sacred Heart Hospital Anyang Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9924-515X","authenticated-orcid":false,"given":"Eun Joo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine, Hallym University Sacred Heart Hospital Anyang Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4158-6100","authenticated-orcid":false,"given":"Kwang Joong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine, Hallym University Sacred Heart Hospital Anyang Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5315-6031","authenticated-orcid":false,"given":"Kwang Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine, Hallym University Sacred Heart Hospital Anyang Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59071245"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.13.1916105"},{"issue":"13","key":"e_1_2_12_4_1","first-page":"2524","article-title":"The Content and Ratio of Type I and III Collagen in Skin Differ With Age and Injury","volume":"10","author":"Cheng W.","year":"2011","journal-title":"African Journal of Biotechnology"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711133372003"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.051302"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.582"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20048"},{"issue":"33","key":"e_1_2_12_9_1","first-page":"S1","article-title":"A 675\u2010nm Laser for Treatment of Facial Aging: A Pilot Study","volume":"53","author":"Ross E. V.","year":"2021","journal-title":"Lasers in Surgery and Medicine"},{"issue":"1","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.det.2023.06.004","article-title":"New Insight Into Nonablative 675\u2010nm Laser Technology","volume":"42","author":"Tolone M.","year":"2024","journal-title":"Dermatologic Clinics"},{"issue":"23","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.3390\/healthcare13233068","article-title":"Combining 675 nm Laser With Isotretinoin for Enhanced Acne Vulgaris Treatment Outcomes","volume":"13","author":"Haus A.","year":"2025","journal-title":"Healthcare"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2023.01.007"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.004"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2020.4927"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-03063-6"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13434"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.46998\/IJCMCR.2024.37.000915"},{"issue":"3","key":"e_1_2_12_18_1","first-page":"146","article-title":"Evaluation of a 3D Image Systems for Objective Facial Measurement","volume":"9","author":"Troilius A.","year":"2007","journal-title":"Journal of Cosmetic and Laser Therapy"},{"issue":"4","key":"e_1_2_12_19_1","first-page":"1234","article-title":"Reliability of a 3D Imaging System for the Evaluation of Facial Morphology","volume":"3","author":"Perez P.","year":"2014","journal-title":"Journal of Clinical Medicine"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29150.x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2001.tb01132.x"},{"issue":"2","key":"e_1_2_12_22_1","first-page":"167","article-title":"Contemporary Uses of 3D Technology in Facial Rejuvenation","volume":"20","author":"Friedman O.","year":"2012","journal-title":"Facial Plastic Surgery Clinics of North America"},{"issue":"4","key":"e_1_2_12_23_1","first-page":"236","article-title":"[Study on the Collagen Constitution of Hyperplastic Scar in Different Ages and Its Influencing Factors]","volume":"19","author":"Qiu L.","year":"2003","journal-title":"Zhonghua Shao Shang za Zhi = Zhonghua Shaoshang Zazhi = Chinese Journal of Burns"},{"issue":"1","key":"e_1_2_12_24_1","first-page":"51","article-title":"[Quantification of Type I and III Collagen Content in Normal Human Skin in Different Age Groups]","volume":"24","author":"Rong Y. H.","year":"2008","journal-title":"Zhonghua Shao Shang Za Zhi = Zhonghua Shaoshang Zazhi = Chinese Journal of Burns"},{"issue":"10","key":"e_1_2_12_25_1","first-page":"2543","article-title":"The Ratio of Collagen Types I\/III as a Marker of Skin Aging and Prognosis of Aesthetic Facial Surgery Results","volume":"10","author":"Manturova N. E.","year":"2018","journal-title":"Journal of Pharmaceutical Sciences and Research"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20453"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.70204","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:01:17Z","timestamp":1788796877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.70204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":25,"alternative-id":["10.1002\/lsm.70204"],"URL":"https:\/\/doi.org\/10.1002\/lsm.70204","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,7]]},"assertion":[{"value":"2026-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"lsm.70204"}}