{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:12:38Z","timestamp":1788797558702,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["147033\/2024\u20101"],"award-info":[{"award-number":["147033\/2024\u20101"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Bioactive surface pre\u2010reacted glass\u2010ionomer (S\u2010PRG) technology and high\u2010power laser irradiation have been investigated as promising preventive approaches. S\u2010PRG particles exhibit multifunctional bioactive glass properties, with the ability to release and recharge ions. High\u2010power laser irradiation of dental enamel induces chemical and structural modifications that enhance enamel resistance. Thus, this study evaluated the effect of Er:YAG laser irradiation, used alone or combined with the bioactive PRG Pro\u2010Care gel, on the reduction of enamel demineralization under cariogenic challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Human enamel specimens were randomly assigned to five groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912): control (C), Herjos prophylactic paste (H), laser (L), PRG Pro\u2010Care gel (PRG), and laser\u2009+\u2009PRG Pro\u2010Care gel (LP). After the treatments, the blocks were subjected to an 8\u2010day pH cycling protocol. The percentage of surface hardness loss (%SHL) was determined through surface microhardness analysis and qualitative analysis was performed by scanning electronic microscopy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Groups L, PRG, and LP showed a significant reduction in mineral loss compared with the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), with the LP protocol being superior to PRG alone (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). No statistically significant difference was observed between groups L and LP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.928). Group H did not differ significantly from group C\u2212 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.205). Treated groups presented physical surface alterations after irradiation and bioactive treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Er:YAG laser irradiation, whether used alone or in combination with the PRG gel, promoted a significant protective effect against enamel demineralization, indicating its potential clinical application in the prevention of dental caries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70206","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:03:16Z","timestamp":1788796996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects of Er:YAG Laser and PRG Pro\u2010Care Gel on Enamel Demineralization"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6228-2344","authenticated-orcid":false,"given":"Joice","family":"Pequeno\u2010da\u2010Silva","sequence":"first","affiliation":[{"name":"Department of Public Health, Pediatric Dentistry and Orthodontics, Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas (UNICAMP) Limeira Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7239-8626","authenticated-orcid":false,"given":"Felipe Fabr\u00edcio","family":"Farias\u2010da\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Public Health, Pediatric Dentistry and Orthodontics, Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas (UNICAMP) Limeira Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5742-5283","authenticated-orcid":false,"given":"Ana Cec\u00edlia Correa","family":"Aranha","sequence":"additional","affiliation":[{"name":"Departament of Restorative Dentistry, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0680-2253","authenticated-orcid":false,"given":"Carolina","family":"Steiner\u2010Oliveira","sequence":"additional","affiliation":[{"name":"Department of Public Health, Pediatric Dentistry and Orthodontics, Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas (UNICAMP) Limeira Brazil"},{"name":"National Institute of Science and Technology in Translational Biophotonics in Dentistry (INCT\u2010BIOFOTO BUCAL)  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503309"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2014.10.010"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242010000500003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-019-02859-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51309"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14040236"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601812010811"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03577-x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2022.104074"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2014.04.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0103-64402008000100004"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000070444"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343573"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-014-1534-3"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-024-04049-4"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76127-w"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.15517\/ijds.2024.62840"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2341\/07-136"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.70206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.70206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:03:17Z","timestamp":1788796997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.70206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":18,"alternative-id":["10.1002\/lsm.70206"],"URL":"https:\/\/doi.org\/10.1002\/lsm.70206","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,7]]},"assertion":[{"value":"2025-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"lsm.70206"}}