{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:54:38Z","timestamp":1791021278994,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study is to compare the effect and safety of carbon dioxide fractional laser (CDFL) and micro\u2010plasma radiofrequency (MPRF) for the treatment of hypertrophic scars (HSs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Symmetric HSs were divided into two sides and randomly treated with either MPRF or CDFL. The Vancouver Scar Scale (VSS), Patient and Observer Scar Assessment Scale (POSAS), shear wave elastography (SWE), and optical coherence tomography angiography (OCTA) were used to compare the changes between baseline and 1 month after the third treatment. The co\u2010primary outcome was the difference in the score of VSS and POSAS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      VSS and POSAS assessments indicated that CDFL primarily improved scar color and vascularity, while MPRF mainly improved scar thickness, elasticity, and hardness. OCTA demonstrated greater changes with CDFL than with MPRF in average vascular diameter (CDFL, 45.84\u2009\u00b1\u20097.68\u2009\u03bcm; MPRF, 32.52\u2009\u00b1\u200910.92\u2009\u03bcm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), density (CDFL, 0.385\u2009\u00b1\u20090.065; MPRF, 0.291\u2009\u00b1\u20090.082;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0166), and complexity (CDFL, 0.217\u2009\u00b1\u20090.046; MPRF, 0.145\u2009\u00b1\u20090.349;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). SWE confirmed greater changes with MPRF than with CDFL in thickness (CDFL, 0.079\u2009\u00b1\u20090.033\u2009cm; MPRF, 0.102\u2009\u00b1\u20090.046\u2009cm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and EM (CDFL, 9.97\u2009\u00b1\u20096.89\u2009kPa; MPRF, 17.54\u2009\u00b1\u20099.35\u2009kPa;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). No significant complications were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both CDFL and MPRF were effective and safe for the treatment of HS, but they improved different scar domains. CDFL produced greater improvement in scar color and vascularity by reducing vascular diameter and density, whereas MPRF led to greater improvement in scar thickness and elasticity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70214","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:11:54Z","timestamp":1791018714000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Carbon Dioxide Fractional Laser Versus Micro\u2010Plasma Radiofrequency for Hypertrophic Scar: A Two\u2010Center, Open\u2010Label, Randomized, Split\u2010Scar Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7583-2547","authenticated-orcid":false,"given":"Yuzhang","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Dermatology, Keloid Research Center Yanbian University Hospital Yanji China"},{"name":"Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"He","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery The First Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianzhen","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery The First Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8495-1952","authenticated-orcid":false,"given":"Libo","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianhua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Laser Medicine The First Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9463-6039","authenticated-orcid":false,"given":"Lixia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Cicatrix Minimally Invasive Treatment Center, Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4642-5795","authenticated-orcid":false,"given":"Youbai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General Hospital Beijing China"},{"name":"Department of Plastic and Reconstructive Surgery The First Medical Center of Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101815"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.103328"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.33274"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.09.018"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0031-0808.20.03970-1"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22666"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2020.0109"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018094"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201500342"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-014-1649-6"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22640"},{"issue":"12","key":"e_1_2_13_13_1","first-page":"1191","article-title":"The 1975 Declaration of Helsinki and Consent","volume":"115","author":"Shephard D. 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