{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:57:54Z","timestamp":1790434674914,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n This exploratory pilot study aims to characterize effective laser settings and evaluate the clinical outcomes and tolerability of a dual\u2010wavelength 532\/1064\u2010nm KTP\/Nd: YAG laser system compared to a 595\u2010nm pulsed dye laser with cryogen spray cooling, across multiple vascular indications, including port\u2010wine capillary malformations (PWCM), erythematous scars, rosacea, venous lakes, and vascular lesions associated with hereditary hemorrhagic telangiectasia.<\/jats:p>\n <\/jats:sec>\n \n Study Design and Methods<\/jats:title>\n Adults with cutaneous vascular conditions were treated with 532\/1064\u2010nm KTP\/Nd: YAG and 595\u2010nm PDL on one to four test spots. Optimal parameters were chosen by the study team. Subjects assessed pain\/discomfort (Scale 0\u201310), edema (Scale 0\u20134), redness (Scale 0\u20134), purpura (Scale 0\u20134), and overall improvement (Scale 0\u20104) post treatment. Blinded physician assessments were collected at the completion of the study.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty\u2010five subjects completed study procedures. The average pulse duration was 10\u2009ms for 532\u2010nm and 1.8\u2009ms for 595\u2010nm laser. Among subjects treated with both lasers and at selected settings, subject\u2010reported outcomes indicated significantly higher pain scores, redness, and purpura following PDL treatment (\n p<\/jats:italic>\n \u2009<\u20090.05). No significant differences were observed for swelling or perceived improvement. In subjects with PWCM, physician\u2010blinded evaluations judged both laser clinical outcomes as equivalent in 60.3% of cases, with KTP\/Nd: YAG favored in 25.4% and PDL in 14.3%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our findings demonstrate that both 532\/1064\u2010nm KTP\/Nd: YAG and 595\u2010nm PDL are effective in the treatment of cutaneous vascular lesions. At selected settings, subjects reported significantly less pain, redness, and purpura following KTP\/Nd: YAG treatment compared to PDL.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lsm.70217","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:00:35Z","timestamp":1790431235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Assessment of 532\/1064\u2010nm KTP\/Nd: YAG and 595\u2010nm Pulsed Dye Laser for Cutaneous Vascular Lesions: A Prospective Split\u2010Site Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-0744","authenticated-orcid":false,"given":"Olamide Sonuga","family":"Finney","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine, University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1468-0682","authenticated-orcid":false,"given":"Feben","family":"Messele","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine, University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9021-4760","authenticated-orcid":false,"given":"Karishma S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine, University of California Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Zachary","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine, University of California Irvine California 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