{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:40:42Z","timestamp":1792622442305,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare a 980\u2010nm diode laser and a 1064\u2010nm nanosecond\u2010pulsed Nd:YAG laser for the excision of benign oral soft\u2010tissue lesions, evaluating thermal alteration, postoperative outcomes, and tissue morphology during healing by optical coherence tomography (OCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were randomly allocated to treatment with either a 980\u2010nm diode laser (Group A) or a 1064\u2010nm nanosecond\u2010pulsed Nd:YAG laser (Group B). OCT was performed before surgery, immediately after excision, and at 2 and 4 weeks. Epithelial (EP) and lamina propria (LP) thicknesses were assessed, while postoperative pain and oral health\u2010related quality of life were evaluated using VAS and OHIP\u201014. Thermal alteration at the surgical margins was quantified histologically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 50 patients were included, with 25 in each group. Both groups showed favorable postoperative outcomes, with generally mild pain and low analgesic consumption. OHIP\u201014 scores were descriptively lower in Group B, without statistically significant differences. Thermal alteration was significantly greater with the diode laser than with the 1064\u2010nm nanosecond\u2010pulsed Nd:YAG laser (494.48\u2009\u00b1\u2009156.97\u2009\u03bcm vs. 253.81\u2009\u00b1\u200977.38\u2009\u03bcm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). At 4 weeks, OCT showed no significant differences in EP and LP thicknesses between groups, although both remained different from the healthy contralateral mucosa.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both laser modalities provided favorable clinical outcomes and specimens suitable for histopathological diagnosis. The 1064\u2010nm nanosecond\u2010pulsed Nd:YAG laser resulted in significantly lower thermal alteration than the 980\u2010nm diode laser, while OCT showed comparable tissue morphology at 4 weeks. These findings suggest a potential advantage of the nanosecond\u2010pulsed Nd:YAG laser when minimizing thermal damage is a priority.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.70221","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:16:01Z","timestamp":1792620961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thermal Tissue Damage and Healing After Laser Excision of Benign Oral Soft\u2010Tissue Lesions: An Optical Coherence Tomography (OCT)\u2010Based Comparison of 980\u2010nm Diode and 1064\u2010nm Nanosecond\u2010Pulsed Nd:YAG Laser"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0130-0799","authenticated-orcid":false,"given":"Alessio","family":"Gambino","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, CIR Dental School University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Moscufo","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, CIR Dental School University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9409-5236","authenticated-orcid":false,"given":"Adriana","family":"Cafaro","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, CIR Dental School University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ercole","family":"Romagnoli","sequence":"additional","affiliation":[{"name":"Private Dental Practice Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9032-2571","authenticated-orcid":false,"given":"Madalina Maria","family":"Lepadatu","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, CIR Dental School University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Chiusa","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Pathology Unit, \u201cCitt\u00e0 della Salute e della Scienza\u201d University Hospital, University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Coscia","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, CIR Dental School University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, CIR Dental School University of Turin Turin Italy"},{"name":"Department of Mechanical and Aerospace Engineering Politecnico of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-7834","authenticated-orcid":false,"given":"Paolo Giacomo","family":"Arduino","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, CIR Dental School University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.19387"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.20556"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.53795"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)45731-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5131(02)01289-X"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23812"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-3-319-51944-9_4","volume-title":"Lasers in Dentistry\u2014Current Concepts","author":"Selting 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