{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:02:49Z","timestamp":1785888169860,"version":"3.56.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4230,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Human herpesvirus 8 (HHV-8) is associated with the development of Kaposi\u2019s sarcoma (KS) and rare lymphoproliferative disorders in immunosuppressed patients. The risk of HHV-8 transmission by liver transplantation and the clinical manifestations of primary infection in this setting have yet to be determined. In order to evaluate this risk, we measured the seroprevalence of HHV-8 among 122 liver donors and their respective recipients before and after transplantation. Molecular methods and immunohistochemical analyses were performed to study the features of HHV-8 infection. Antibodies to HHV-8 were detected in sera of 4 donors before transplantation (3.3%) and of 3 recipients (2.4%). None of the 3 recipients, who were HHV-8 seropositive before transplantation, developed a KS during the follow-up. Four primary HHV-8 infections were detected among the 4 HHV-8 seronegative recipients who received a liver from an HHV-8 positive donor. Among these 4 recipients, 2 particularly immunosuppressed patients developed symptomatic diseases and died a few months after transplantation, harboring disseminated KS and HHV-8 positive lymphoproliferation. In these 2 patients, HHV-8 DNA genome sequences were detectable in peripheral blood mononuclear cells and other tissues with high viremia levels before and at the beginning of HHV-8-related diseases. In conclusion, in liver transplantation recipients, HHV-8 primary infection can be associated with fatal outcome. This study raises the question of screening liver donors for HHV-8\u2014even in low HHV-8 infection prevalence countries\u2014not systematically to exclude the graft but to monitor, clinically and biologically, patients who received a graft from an HHV-8-infected donor. (Liver Transpl 2004;10:295-300.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.20058","type":"journal-article","created":{"date-parts":[[2004,1,31]],"date-time":"2004-01-31T00:00:52Z","timestamp":1075507252000},"page":"295-300","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":62,"title":["Fatal disseminated Kaposi\u2019s sarcoma following human herpesvirus 8 primary infections in liver-transplant recipients"],"prefix":"10.1097","volume":"10","author":[{"given":"Anne-Genevi\u00e8ve","family":"Marcelin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Roque-Afonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Hurtova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dupin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micheline","family":"Tulliez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myl\u00e8ne","family":"Sebagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Za\u00efna Ait","family":"Arkoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Guettier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Samuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Calvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Dussaix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20250326","doi-asserted-by":"crossref","first-page":"439464","DOI":"10.1128\/CMR.15.3.439-464.2002","article-title":"Spectrum of Kaposis sarcoma-associated herpesvirus, or human herpesvirus 8, diseases.","volume":"15","author":"Ablashi","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"R2-19-20250326","doi-asserted-by":"crossref","first-page":"10271038","DOI":"10.1056\/NEJM200004063421407","article-title":"Kaposis sarcoma.","volume":"342","author":"Antman","year":"2000","journal-title":"N Engl J Med"},{"key":"R3-19-20250326","doi-asserted-by":"crossref","first-page":"373382","DOI":"10.1038\/nrc797","article-title":"AIDS-related malignancies.","volume":"2","author":"Boshoff","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"R4-19-20250326","doi-asserted-by":"crossref","first-page":"664670","DOI":"10.1038\/sj.leu.2401390","article-title":"Primary effusion lymphoma after heart transplantation: a new entity associated with human herpesvirus-8.","volume":"13","author":"Dotti","year":"1999","journal-title":"Leukemia"},{"key":"R6-19-20250326","first-page":"444449","article-title":"Jones, D, Ballestas, ME, Kaye, KM, et al. 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