{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:24:41Z","timestamp":1773433481713,"version":"3.50.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4048,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>With the aim of assessing whether fenoldopam can help to preserve renal function after liver transplantation, we randomized 140 consecutive recipients with comparable preoperative renal function to receive fenoldopam 0.1 \u03bcg\/kg\/minute (group F, 46 patients), dopamine 3 \u03bcg\/kg\/minute (group D, 48 patients), or placebo (group P, 46 patients) from the time of anesthesia induction to 96 hours postoperatively. There were no differences between the groups in intraoperative urinary output or furosemide administration (both <jats:italic toggle=\"yes\">P<\/jats:italic> = .1). Daily recordings made during the first 4 postoperative days revealed no significant differences in urinary output (<jats:italic toggle=\"yes\">P<\/jats:italic> = .1), serum creatinine (<jats:italic toggle=\"yes\">P<\/jats:italic> = .5), the incidence of renal insufficiency (<jats:italic toggle=\"yes\">P<\/jats:italic> = .7), the need for loop diuretics (<jats:italic toggle=\"yes\">P<\/jats:italic> = .9) or vasoactive drugs (<jats:italic toggle=\"yes\">P<\/jats:italic> = .8). In comparison with preoperative levels, creatinine clearance at the end of the study in the patients receiving fenoldopam remained substantially unchanged, whereas it decreased by 39 and 12.3%, respectively, in the subjects receiving placebo or dopamine (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .001); blood cyclosporine A (CsA) levels were similar in the 3 groups (<jats:italic toggle=\"yes\">P<\/jats:italic> = .1). Three subjects died in the intensive care unit (1 in each group, <jats:italic toggle=\"yes\">P<\/jats:italic> = .9), 2 of them had renal failure. In conclusion, our results confirm the inefficacy of dopamine in preventing or limiting early renal dysfunction after liver transplantation, and suggest that fenoldopam may preserve creatinine clearance by counterbalancing the renal vasoconstrictive effect of CsA, as it has been reported in previous experimental studies. 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