{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T07:03:51Z","timestamp":1781161431814,"version":"3.54.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4048,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Important innovations, such as hepatitis B immune globulin (HBIG) and lamivudine, have been introduced to the care of patients undergoing liver transplantation (OLT) for viral hepatitis B (HBV) (over the last 15 years). We analyzed survival of OLT recipients with HBV in the United States to examine the effect of these innovations. A retrospective analysis was conducted based on data collected prospectively by the United Network for Organ Sharing in all adult (older than 18) patients undergoing primary OLT in the United States between 1987 and 2002. OLT recipients with HBV were identified by the principal diagnosis of acute or chronic HBV or positive results on HBV markers. Patients were divided into Era 1 (1987-1991), Era 2 (1992-1996), and Era 3 (1997-2002). Era 1 consisted of 6,708 patients (675 with HBV), Era 2 consisted of 13,995 patients (1,005 with HBV), and Era 3 consisted of 20,730 patients (1,723 with HBV). More recent patients were older and had less advanced liver disease and shorter ischemic time. The survival of patients with HBV was significantly better for Era 2 than for Era 1 (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .01) and for Era 3 than for Era 2 (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .01). There was no difference in survival between patients with HBV and all other diagnoses for Era 3 (<jats:italic toggle=\"yes\">P<\/jats:italic> = .14). In the multivariable analysis, the effect of these eras persisted when other variables such as recipient and donor age, warm ischemic time, pre-OLT disease severity, and hepatocellular carcinoma (HCC) were taken into account. Unlike previous reports, fulminant disease and Asian race had no effect on patient survival. In conclusion, these data underscore the effectiveness of therapeutic innovations that have occurred in the past two decades and indicate timely and widespread adoption of these measures by transplant centers nationwide. (Liver Transpl 2004;10:968-974.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.20217","type":"journal-article","created":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T17:09:19Z","timestamp":1090602559000},"page":"968-974","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":161,"title":["Outcome of liver transplantation for hepatitis B in the United States"],"prefix":"10.1097","volume":"10","author":[{"given":"Ray W.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Poterucha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter K.","family":"Kremers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Ishitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolland E.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-2-20250326","doi-asserted-by":"crossref","first-page":"150157","DOI":"10.1002\/hep.1840130122","article-title":", Hepatic histological findings after transplantation for chronic hepatitis B virus infection, including a unique pattern of fibrosing cholestatic hepatitis.","volume":"13","author":"Davies","year":"1991","journal-title":"Hepatology"},{"key":"R2-2-20250326","doi-asserted-by":"crossref","first-page":"619626","DOI":"10.1002\/hep.1840130402","article-title":"Orthotopic liver transplantation for patients with hepatitis B virus-related liver disease.","volume":"13","author":"Todo","year":"1991","journal-title":"Hepatology"},{"key":"R3-2-20250326","first-page":"104111","article-title":", Hepatitis B virus reinfection after orthotopic liver transplantation. 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Lamivudine Transplant Group.","volume":"29","author":"Perrillo","year":"1999","journal-title":"Hepatology"},{"key":"R18-2-20250326","doi-asserted-by":"crossref","first-page":"129134","DOI":"10.1053\/jhep.2000.8626","article-title":", Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants.","volume":"32","author":"Perrillo","year":"2000","journal-title":"Hepatology"},{"key":"R20-2-20250326","doi-asserted-by":"crossref","first-page":"424432","DOI":"10.1053\/jhep.2001.21554","article-title":", A multicenter United States-Canadian trial to assess lamivudine monotherapy before and after liver transplantation for chronic hepatitis B.","volume":"33","author":"Perrillo","year":"2001","journal-title":"Hepatology"},{"key":"R21-2-20250326","doi-asserted-by":"crossref","first-page":"715721","DOI":"10.1016\/S0168-8278(99)80204-9","article-title":", High pre-treatment serum hepatitis B virus titer predicts failure of lamivudine prophylaxis and graft re-infection after liver transplantation.","volume":"30","author":"Mutimer","year":"1999","journal-title":"J Hepatol"},{"key":"R22-2-20250326","doi-asserted-by":"crossref","first-page":"433439","DOI":"10.1053\/jlts.2002.32983","article-title":", Effect of lamivudine treatment on survival of 309 North American patients awaiting liver transplantation for chronic hepatitis B.","volume":"8","author":"Fontana","year":"2002","journal-title":"Liver Transpl"},{"key":"R23-2-20250326","doi-asserted-by":"crossref","first-page":"860863","DOI":"10.1136\/gut.49.6.860","article-title":", Acute liver graft failure due to emergence of lamivudine resistant hepatitis B virus: rapid resolution during treatment with adefovir.","volume":"49","author":"Mutimer","year":"2001","journal-title":"Gut"},{"key":"R25-2-20250326","doi-asserted-by":"crossref","first-page":"15281535","DOI":"10.1053\/jhep.2002.33681","article-title":", Increasing applicability of liver transplantation for patients with hepatitis B-related liver disease.","volume":"35","author":"Steinmuller","year":"2002","journal-title":"Hepatology"},{"key":"R26-2-20250326","doi-asserted-by":"crossref","first-page":"333339","DOI":"10.1002\/hep.1840210211","article-title":", Long-term clinical and virological outcome after liver transplantation for cirrhosis caused by chronic delta hepatitis.","volume":"21","author":"Samuel","year":"1995","journal-title":"Hepatology"},{"key":"R27-2-20250326","first-page":"469471","article-title":", Liver transplantation in hepatitis delta virus disease.","volume":"2","author":"Rizzetto","year":"1987","journal-title":"Lancet"},{"key":"R28-2-20250326","doi-asserted-by":"crossref","first-page":"16491655","DOI":"10.1016\/0016-5085(91)90404-9","article-title":", Patterns of hepatitis delta virus reinfection and disease in liver transplantation.","volume":"101","author":"Ottobrelli","year":"1991","journal-title":"Gastroenterology"},{"key":"R29-2-20250326","first-page":"19041906","article-title":", Liver transplantation for chronic hepatitis B in Asian males.","volume":"25","author":"Jacobs","year":"1993","journal-title":"Transplant Proc"},{"key":"R30-2-20250326","doi-asserted-by":"crossref","first-page":"223225","DOI":"10.1002\/hep.510250140","article-title":"Liver transplantation in Asian patients with chronic hepatitis B.","volume":"25","author":"Ho","year":"1997","journal-title":"Hepatology"},{"key":"R31-2-20250326","doi-asserted-by":"crossref","first-page":"126132","DOI":"10.1053\/jhep.2001.25271","article-title":", Liver transplantation in patients with hepatitis B virus infection: outcome in Asian versus white patients.","volume":"34","author":"Teo","year":"2001","journal-title":"Hepatology"},{"key":"R32-2-20250326","doi-asserted-by":"crossref","first-page":"287293","DOI":"10.1016\/S0140-6736(02)07494-9","article-title":"Effect of race on outcome of orthotopic liver transplantation: a cohort study.","volume":"359","author":"Nair","year":"2002","journal-title":"Lancet"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.20217","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-200408000-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T10:47:27Z","timestamp":1743245247000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-200408000-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.20217","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}