{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:35:31Z","timestamp":1780731331341,"version":"3.54.1"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3864,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:bold>Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is a rare complication of pregnancy that is associated with preeclampsia and may result in rupture of the liver. Although there have been case reports of liver transplantation for HELLP syndrome, the outcomes of transplantation for this rare indication have not been reported. Furthermore, the optimal management of complicated HELLP syndrome and indications for liver transplantation are unclear. Our objective was to review the national experience with liver transplantation for HELLP syndrome and to develop a comprehensive algorithm for the management of liver complications of HELLP syndrome, including indications for transplantation. A recent case from our institution is reported and the literature is reviewed. The results of liver transplantation for HELLP syndrome were analyzed from the United Network for Organ Sharing database. Between October 1987 and November 2003 there have been 8 deceased donor liver transplants performed for complications related to HELLP syndrome. As of the most recent follow-up, 6 of the 8 patients are alive, with both deaths occurring within 1 month of transplantation, and 2 patients have required retransplantation. This review supports that good results can be obtained with liver transplantation for patients with complicated HELLP syndrome that have either ongoing, uncontrolled hemorrhage or liver necrosis and failure. Patients with complicated HELLP syndrome are best managed at a center with expertise in liver transplantation. (Liver Transpl 2005;11:224\u2013228.)<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.20285","type":"journal-article","created":{"date-parts":[[2005,1,21]],"date-time":"2005-01-21T17:47:48Z","timestamp":1106329668000},"page":"224-228","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":76,"title":["Liver transplantation for HELLP syndrome"],"prefix":"10.1097","volume":"11","author":[{"given":"Brian D.","family":"Shames","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans W.","family":"Sollinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"D'Alessandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J.","family":"Knechtle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Lucey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Hafez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru I.","family":"Musat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munci","family":"Kalayoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20250326","first-page":"1258","article-title":"Maternal and perinatal outcome in severe pregnancyrelated liver disease.","volume":"26","author":"Pereira","year":"1997","journal-title":"Hepatology"},{"key":"R2-15-20250326","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1056\/NEJM199608223350807","article-title":"Liver disease in pregnancy.","volume":"335","author":"Knox","year":"1996","journal-title":"N Engl J Med"},{"key":"R3-15-20250326","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/0002-9378(93)90043-I","article-title":"Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome).","volume":"169","author":"Sibai","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"R4-15-20250326","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1471-0528.1997.tb14346.x","article-title":"The HELLP syndrome.","volume":"104","author":"Geary","year":"1997","journal-title":"Br J Obstet Gynaecol"},{"key":"R5-15-20250326","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1097\/00006254-197611000-00001","article-title":"Rupture of the liver associated with pregnancy: A review of the literature and report of 2 cases.","volume":"31","author":"Bis","year":"1976","journal-title":"Obstet Gynecol Surv"},{"key":"R6-15-20250326","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/S0002-9378(97)70353-3","article-title":"Spontaneous liver hematoma in pregnancy not clearly associated with preeclampsia: A case presentation and literature review.","volume":"176","author":"Schwartz","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"R7-15-20250326","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/00006254-198906000-00001","article-title":"Hepatic rupture in pregnancy.","volume":"44","author":"Neerhof","year":"1989","journal-title":"Obstet Gynecol Surv"},{"key":"R8-15-20250326","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/BF01789221","article-title":"Auxiliary partial orthotopic liver transplantation (APOLT) for fulminant hepatic failure: First successful case report.","volume":"15","author":"Gubernatis","year":"1991","journal-title":"World J Surg"},{"key":"R9-15-20250326","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1432-2277.1993.tb00643.x","article-title":"Acute liver necrosis in the HELLP syndrome: A successful outcome after orthotopic liver transplantation. A case report.","volume":"6","author":"Erhard","year":"1993","journal-title":"Transpl Int"},{"key":"R10-15-20250326","first-page":"298","article-title":"Liver complications of HELLP syndromean indication for emergency liver transplantation?","volume":"119","author":"Erhard","year":"1994","journal-title":"Zentralbl Chir"},{"key":"R11-15-20250326","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1055\/s-2007-1023130","article-title":"Die schwere Leberruptr beim HELLPsyndrom. 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