{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:46:34Z","timestamp":1790930794634,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3775,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:bold>Graft dysfunction mimicking autoimmune hepatitis rarely develops after liver transplantation for nonautoimmune disease. The mechanism(s) and causes of de novo autoimmune hepatitis are unknown. We examined autoantibodies serially in a patient with de novo autoimmune hepatitis and in patients without de novo autoimmune hepatitis after liver transplantation. Anticytokeratin 8\/18 antibodies were detected in the first patient's sera after the onset of de novo autoimmune hepatitis, whereas other patients without de novo autoimmune hepatitis were seronegative throughout the follow-up period even with acute cellular rejection or other cause of liver dysfunction. In conclusion, the changes in cytokeratin 8\/18 in hepatocytes might be one of the sources of pathogenesis of de novo autoimmune hepatitis after liver transplantation. (Liver Transpl 2005;11:504\u2013507.)<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.20404","type":"journal-article","created":{"date-parts":[[2005,4,18]],"date-time":"2005-04-18T14:49:04Z","timestamp":1113835744000},"page":"504-507","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":39,"title":["Antibodies against cytokeratin 8\/18 in a patient with de novo autoimmune hepatitis after living-donor liver transplantation"],"prefix":"10.1097","volume":"11","author":[{"given":"Ayano","family":"Inui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Sogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Miyakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20250326","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0140-6736(97)06478-7","article-title":"Denovo autoimmune hepatitis after liver transplantation.","volume":"351","author":"Kerkar","year":"1998","journal-title":"Lancet"},{"key":"R2-6-20250326","first-page":"262","article-title":"Posttransplant immune hepatitis in pediatric liver transplant recipients: incidence and maintenance therapy with azathioprine.","volume":"72","author":"Andres","year":"2001","journal-title":"Transplantation"},{"key":"R3-6-20250326","first-page":"131","article-title":"Autoimmune hepatitis as a late complication of liver transplantation.","volume":"32","author":"Hernandez","year":"2001","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"R4-6-20250326","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1053\/jhep.2001.26756","article-title":"Graft dysfunction mimicking autoimmune hepatitis following liver transplantation in adults.","volume":"34","author":"Heneghan","year":"2001","journal-title":"Hepatology"},{"key":"R5-6-20250326","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/00007890-200103150-00016","article-title":"De novo hepatitis with autoimmune antibodies and atypical histology.","volume":"71","author":"Gupta","year":"2001","journal-title":"Transplantation"},{"key":"R6-6-20250326","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1053\/jhep.2002.31167","article-title":"Response to steroids in de novo autoimmune hepatitis after liver transplantation.","volume":"35","author":"Salcedo","year":"2002","journal-title":"Hepatology"},{"key":"R7-6-20250326","doi-asserted-by":"crossref","first-page":"364A","DOI":"10.1016\/S0270-9139(03)80465-2","article-title":"Possible predictive and diagnostic role of antiSLA antibodies in de novo autoimmune hepatitis after liver transplantation.","volume":"38","author":"Hadzic","year":"2003","journal-title":"Hepatology"},{"key":"R8-6-20250326","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1365-2249.2001.01682.x","article-title":"Antibodies against glutathione Stransferase T1 (GSTT1) in patients with de novo immune hepatitis following liver transplantation.","volume":"126","author":"Aguilera","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"R9-6-20250326","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0896-8411(03)00084-2","article-title":"Low frequency of antiSLALP autoantibody in Japanese adult patients with autoimmune liver diseases: analysis with recombinant antigen assay.","volume":"21","author":"Miyakawa","year":"2003","journal-title":"J Autoimmun"},{"key":"R10-6-20250326","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International Autoimmune Hepatitis Group Reports: review of criteria for diagnosis of autoimmune hepatitis.","volume":"31","author":"Alvares","year":"1999","journal-title":"J Hepatol"},{"key":"R11-6-20250326","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/hep.510250328","article-title":"Banff schema for grading liver allograft rejection: an international consensus document.","volume":"25","year":"1997","journal-title":"Hepatology"},{"key":"R12-6-20250326","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/00007890-200201150-00015","article-title":"Late cellular rejection in paediatric liver transplantation: aetiology and outcome.","volume":"73","author":"DAntiga","year":"2002","journal-title":"Transplantation"},{"key":"R13-6-20250326","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1034\/j.1399-0012.1999.130404.x","article-title":"Severe late acute allograft rejection in a child after livingrelated auxiliary partial orthotopic liver transplantation for orhithine transcarbamylase deficiency.","volume":"13","author":"Komatsu","year":"1999","journal-title":"Clin Transplantation"},{"key":"R14-6-20250326","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/01.TP.0000132328.33460.43","article-title":"Outcome and risk factors of de novo autoimmune hepatitis in livingdonor liver transplantation.","volume":"78","author":"Miyagawa","year":"2004","journal-title":"Transplantation"},{"key":"R15-6-20250326","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1600-0676.1993.tb00617.x","article-title":"Cytokeratins and the liver.","volume":"13","author":"Van Eyken","year":"1993","journal-title":"Liver"},{"key":"R16-6-20250326","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1083\/jcb.111.3.1197","article-title":"A single human keratin 18 gene is expressed in diverse epithelial cells of transgenic mice.","volume":"111","author":"Abe","year":"1990","journal-title":"J Cell Biol"},{"key":"R17-6-20250326","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1083\/jcb.131.5.1303","article-title":"Chronic hepatitis, hepatocytes fragility, and increased soluble phsphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant.","volume":"131","author":"Ku","year":"1995","journal-title":"J Cell Biol"},{"key":"R18-6-20250326","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1172\/JCI118864","article-title":"Susceptibility to hepatotoxicity in transgenic mice that express a dominantnegative human keratin 18 mutant.","volume":"98","author":"Ku","year":"1996","journal-title":"J Clin Invest"},{"key":"R19-6-20250326","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/hep.510280117","article-title":"Protein phosphatase inhibition in normal and keratin 8 18 assemblyincompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity.","volume":"28","author":"Toivola","year":"1998","journal-title":"Hepatology"},{"key":"R20-6-20250326","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI119127","article-title":"Mutation of human keratin 18 in association with cryptogenic cirrhosis.","volume":"99","author":"Ku","year":"1997","journal-title":"J Clin Invest"},{"key":"R21-6-20250326","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1056\/NEJM200105243442103","article-title":"Keratin 8 mutations in patients with cryptogenic liver disease.","volume":"344","author":"Ku","year":"2001","journal-title":"N Engl J Med"},{"key":"R22-6-20250326","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1073\/pnas.0936165100","article-title":"Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies.","volume":"100","author":"Ku","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R23-6-20250326","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1053\/jhep.2002.31165","article-title":"Keratins: guardians of the liver.","volume":"35","author":"Omary","year":"2002","journal-title":"Hepatology"},{"key":"R25-6-20250326","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1365-2249.2001.01568.x","article-title":"Anticytokeratin antibodies in sera of the patients with autoimmune hepatitis.","volume":"125","author":"Murota","year":"2001","journal-title":"Clin Exp Immunol"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.20404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-200505000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T15:04:37Z","timestamp":1743260677000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-200505000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.20404","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}