{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:14:49Z","timestamp":1783098889922,"version":"3.54.6"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3652,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:bold>Posttransplant chronic renal failure, secondary to calcineurin inhibitor agents, is emerging as a major problem in liver transplantation. We report a randomized clinical trial comparing daclizumab, delayed low-dose tacrolimus (target trough level 4-8 ng\/mL, starting day 4-6), Investigational Arm (n = 72), to standard tacrolimus induction\/maintenance dosing, Standard Arm (n = 76), with mycophenolate mofetil and tapering corticosteroids in both study arms. The end-points were renal function indicated by the Modification of Diet in Renal Disease (MDRD). There was no significant difference in patient survival (86.6% Investigational Arm vs. 92.9% Standard Arm;<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.21) or acute rejection (23.2% vs. 27.7%, respectively;<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.68). Statistically significant differences in median glomerular filtration rate (GFR) were found in favor of the Investigational Arm. With the CG equation, the GFR at the end of the first week was 110.7 vs. 89.6 mL\/min (<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.019) without significant differences thereafter. With the MDRD, statistically significant differences extended to the first posttransplant month (86.8 vs. 70.1 mL\/min\/1.73 m2;<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>&lt; 0.001) with and was seen at month 6 (75.4 vs. 69.5 mL\/min\/1.73 m2;<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.038). In conclusion, delayed low-dose tacrolimus, in combination with daclizumab and mycophenolate mofetil, preserves early renal function post-liver transplantation without the cost of increased acute rejection.<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/lt.20490","type":"journal-article","created":{"date-parts":[[2005,8,25]],"date-time":"2005-08-25T17:47:54Z","timestamp":1124992074000},"page":"1064-1072","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":126,"title":["Evaluation of Renal Function in Liver Transplant Recipients Receiving Daclizumab (Zenapax), Mycophenolate Mofetil, and a Delayed, Low-Dose Tacrolimus Regimen Vs. a Standard-Dose Tacrolimus and Mycophenolate Mofetil Regimen"],"prefix":"10.1097","volume":"11","author":[{"given":"Eric M.","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Marotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Greig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman M.","family":"Kneteman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Marleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Cantarovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevork M.","family":"Peltekian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie B.","family":"Lilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Scudamore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent G.","family":"Bain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Balshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.T.","family":"Barkun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20250124","first-page":"1110","article-title":"The U.S. Multicenter FK506 Liver Study Group.","volume":"331","year":"1994","journal-title":"N Engl J Med"},{"key":"R2-9-20250124","first-page":"423","article-title":"European FK506 Multicentre Liver Study Group.","volume":"344","year":"1994","journal-title":"Lancet"},{"key":"R3-9-20250124","first-page":"117","article-title":"The Pittsburgh randomized trial of tacrolimus compared to cyclosporine for hepatic transplantation.","volume":"183","author":"Fung","year":"1996","journal-title":"J Am Coll Surg"},{"key":"R4-9-20250124","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1053\/jlts.2001.23356","article-title":"A randomized double-blind comparative study of mycophenolate mofetil and azathioprine in combination with cyclosporine and corticosteroids in primary liver transplant recipients.","volume":"7","author":"Wiesner","year":"2001","journal-title":"Liver Transpl"},{"key":"R5-9-20250124","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1053\/jlts.2003.50102","article-title":"Early steroid withdrawal after liver transplantation: The Canadian tacrolimus versus microemulsion cyclosporin A trial: 1-year follow-up.","volume":"9","author":"Greig","year":"2003","journal-title":"Liver Transpl"},{"key":"R6-9-20250124","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJM198107303050507","article-title":"Liver transplantation with use of cyclosporin a and prednisone.","volume":"305","author":"Starzl","year":"1981","journal-title":"N Engl J Med"},{"key":"R7-9-20250124","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00007890-199807150-00010","article-title":"Chronic renal failure following liver transplantation: A retrospective analysis.","volume":"66","author":"Fisher","year":"1998","journal-title":"Transplantation"},{"key":"R8-9-20250124","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1053\/jlts.2002.35668","article-title":"Chronic renal dysfunction late after liver transplantation.","volume":"8","author":"Cohen","year":"2002","journal-title":"Liver 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with interferon.","volume":"15","author":"Shapiro","year":"1995","journal-title":"Am J Nephrol"},{"key":"R23-9-20250124","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/00313029500169053","article-title":"Renal glomerular lesions in unselected patients with cirrhosis undergoing orthotopic liver transplantation.","volume":"27","author":"Axelsen","year":"1995","journal-title":"Pathology"},{"key":"R24-9-20250124","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1053\/gast.1996.v110.pm8536866","article-title":"Cryoglobulinemia presenting after liver transplantation.","volume":"110","author":"Gournay","year":"1996","journal-title":"Gastroenterology"},{"key":"R25-9-20250124","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1053\/jlts.2002.31745","article-title":"Post-liver transplantation diabetes mellitus: An association with hepatitis C.","volume":"8","author":"Aldosary","year":"2002","journal-title":"Liver 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dysfunction.","volume":"69","author":"Cantarovich","year":"2003","journal-title":"Transplantation"},{"key":"R29-9-20250124","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00007890-200001270-00019","article-title":"Experience with daclizumab in liver transplantation: Renal transplant dosing without calcineurin inhibitors is insufficient to prevent acute rejection in liver transplantation.","volume":"69","author":"Hirose","year":"2000","journal-title":"Transplantation"},{"key":"R30-9-20250124","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/lt.20213","article-title":"Hepatitis C etiology of liver disease is strongly associated with early acute rejection following liver transplantation.","volume":"10","author":"McTaggart","year":"2004","journal-title":"Liver Transpl"},{"key":"R31-9-20250124","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1053\/jlts.2001.29414","article-title":"Anti-interleukin-2 receptor therapy in combination with mycophenolate mofetil is associated with more severe hepatitis C recurrence after liver transplantation.","volume":"7","author":"Nelson","year":"2001","journal-title":"Liver Transpl"},{"issue":"suppl C","key":"R32-9-20250124","doi-asserted-by":"crossref","first-page":"27C","DOI":"10.1155\/2004\/402743","article-title":"Renal dysfunction in liver transplantation: The problem and preventive strategies.","volume":"18","author":"Cantarovich","year":"2004","journal-title":"Can J Gastroenterol"},{"key":"R33-9-20250124","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/lt.20017","article-title":"Estimation of glomerular filtration rates before and after orthotopic liver transplantation: Evaluation of current equations.","volume":"10","author":"Gonwa","year":"2004","journal-title":"Liver Transpl"},{"key":"R34-9-20250124","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/01.TP.0000114609.99558.41","article-title":"Early kidney dysfunction post liver transplantation predicts late chronic kidney disease.","volume":"77","author":"Velidedeoglu","year":"2004","journal-title":"Transplantation"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flt.20490","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-200509000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T16:05:26Z","timestamp":1737734726000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-200509000-00009"}},"subtitle":["A Multicenter Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.1002\/lt.20490","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}